337915-79-4

Basic information

• Product Name: 1,2-BENZENEDIAMINE, 4-BROMO-N2-METHYL-
• Synonyms: 1,2-BENZENEDIAMINE, 4-BROMO-N2-METHYL-;4-Bromo-2-methylaminoaniline;4-Bromo-N2-methyl-1,2-benzenediamine;5-Bromo-N1-methylbenzene-1,2-diamine;4-bromo-N2-methyl-benzene-1,2-diamine
• CAS NO: 337915-79-4
• Molecular Formula: C₇H₉BrN₂
• Molecular Weight: 201.066
• Mol File: 337915-79-4.mol
• Article Data: 39

Chemical Properties

• Boiling Point: 289℃
• Flash Point: 129℃
• Appearance: /
• Density: 1.578
• Vapor Pressure: 0.00225mmHg at 25°C
• Refractive Index: 1.673
• Storage Temp.: 2-8°C(protect from light)
• PKA: 5.85±0.10(Predicted)
• CAS DataBase Reference: 1,2-BENZENEDIAMINE, 4-BROMO-N2-METHYL-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-BENZENEDIAMINE, 4-BROMO-N2-METHYL-(337915-79-4)
• EPA Substance Registry System: 1,2-BENZENEDIAMINE, 4-BROMO-N2-METHYL-(337915-79-4)

Safety Data

• Hazardous Substances Data: 337915-79-4(Hazardous Substances Data)

Usage

General Description

1,2-Benzenediamine, 4-Bromo-N2-Methyl- is a chemical compound with the formula C7H9BrN2. It is an aromatic amine that belongs to the family of anilines and derivatives. Its key features include a benzene ring substituted by a bromo group and two amine groups, one of which is further substituted by a methyl group. This chemical is utilized in various applications in the field of industrial synthesis, especially in the origination of more complicated organic molecules. Due to its reactivity and potential health effects, it is recommended that users adhere to strict safety protocols while handling this chemical compound.

InChI:InChI=1/C7H9BrN2/c1-10-7-4-5(8)2-3-6(7)9/h2-4,10H,9H2,1H3

Upstream product

• 5228-61-5 5-bromo-2-nitroaniline 
• 367-24-8 4-bromo-2-fluoroaniline 
• 875-51-4 4-Bromo-2-nitroaniline 
• 53484-26-7 N-methyl-4-bromo-2-nitroaniline 
• 321-23-3 4-bromo-2-fluoronitrobenzene 
• 302800-13-1 5-bromo-N-methyl-2-nitroaniline 

Downstream Products

• 53484-16-5 6-bromo-1-methyl-1H-benzo[d]imidazole 
• 84712-08-3 5-bromo-1-methyl-1,3-dihydro-2H-benzo[d]imidazole-2-one 
• 305790-48-1 6-bromo-1-methyl-1,3-dihydro-2H-benzo[d]imidazole-2-one 
• 1378947-22-8 6-bromo-2-chloro-1-methyl-1H-benzo[d]imidazole 

Relevant articles and documents

1H-BENZO[D]IMIDAZOLE DERIVATIVES AS TLR9 INHIBITORS FOR THE TREATMENT OF FIBROSIS

The present invention relates to lH-benzo[d]imidazole derivatives of formula (I) or a salt thereof. The present compounds are inhibitors of TLR9 and useful in treating preventing, or slowing fibrotic diseases, such as e.g. liver fibrosis, renal fibrosis, biliary fibrosis or pancreatic fibrosis, nonalcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), chronic kidney disease, diabetic kidney disease, primary sclerosing cholangitis (PSC) or primary biliary cirrhosis (PBC), or idiopathic pulmonary fibrosis (IPF).

Cu-Catalyzed C-H Allylation of Benzimidazoles with Allenes

CuH-catalyzed intramolecular cyclization and intermolecular allylation of benzimidazoles with allenes have been described. The reaction proceeded smoothly with the catalytic system of Cu(OAc)2/Xantphos and catalytic amount of (MeO)2MeSiH. This protocol features mild reaction conditions and a good tolerance of substrates bearing electron-withdrawing, electron-donating, or electron-neutral groups. A new catalytic mechanism was proposed for this copper hydride catalytic system.

MDM2 DEGRADERS AND USES THEREOF

The present invention relates to compounds and methods useful for the modulation of mouse double minute 2 homolog ("MDM2") protein via ubiquitination and/or degradation by compounds according to the present invention.