337980-36-6

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-ETHOXY-PHENYL)-5-METHYL-1H-[1,2,3]TRIAZOLE-4-CARBOXYLIC ACID is used as a building block for the synthesis of various bioactive compounds. Its unique structure and functional groups make it a versatile intermediate for the design and development of new drug candidates.
Used in Antimicrobial Applications:
1-(4-ETHOXY-PHENYL)-5-METHYL-1H-[1,2,3]TRIAZOLE-4-CARBOXYLIC ACID may be used as an antimicrobial agent due to its potential biological activities, which include antimicrobial properties.
Used in Antifungal Applications:
Similarly, 1-(4-ETHOXY-PHENYL)-5-METHYL-1H-[1,2,3]TRIAZOLE-4-CARBOXYLIC ACID may also be utilized as an antifungal agent, given its possible antifungal properties.
Used in Anticancer Applications:
1-(4-ETHOXY-PHENYL)-5-METHYL-1H-[1,2,3]TRIAZOLE-4-CARBOXYLIC ACID may exhibit anticancer properties, making it a potential candidate for the development of new cancer treatments.
Used in Drug Discovery and Development:
As a chemical compound with various potential biological activities, 1-(4-ethoxy-phenyl)-5-methyl-1H-[1,2,3]triazole-4-carboxylic acid serves as an important tool in drug discovery and development, particularly for the synthesis of novel bioactive compounds with potential applications in various therapeutic areas.

Upstream product

• 98488-09-6 1-azido-4-ethoxybenzene 
• 141-97-9 ethyl acetoacetate 
• 869726-08-9 ethyl 1-(4-ethoxyphenyl)-5-methyl-1,2,3-triazol-4-carboxylate 
• 156-43-4 4-Ethoxyaniline 

Downstream Products

• 869726-08-9 ethyl 1-(4-ethoxyphenyl)-5-methyl-1,2,3-triazol-4-carboxylate 
• 869726-09-0 1-(4-ethoxyphenyl)-5-methyl-1,2,3-triazol-4-carbonylhydrazine 
• 861243-19-8 1-amino-5-[1-(4-ethoxyphenyl)-5-methyl-1,2,3-triazol-4-yl]-2-sulfanyl-1,3,4-triazole 
• 88958-26-3 C₁₂H₁₂ClN₃O₂ 

Relevant academic research and scientific papers

The synthesis and crystal structure of new 3,6-bis[1-(4-ethoxyphenyl)-5- methyl-1,2,3- triazol-4-yl]-s-triazolo[3,4-b]-1,3,4-thiadiazole

The 3,6-bis[1-(4-ethoxyphenyl)-5-methyl-1,2,3-triazol-4-yl]-s-triazolo[3,4- b]-1,3,4-thiad- iazole was synthesized from p-ethoxyaniline to 8 with 1-(4-ethoxyphenyl)-5-methyl-1,2,3-triazol-4-caroxylic acid. The yielded product 9 was investigated with X-ray

Design, synthesis and biological studies of some new imidazole-1,2,3-triazole hybrid derivatives

Some new 4-((1H-imidazol-1-yl)diarylmethyl)-5-methyl-1-aryl-1H-1,2,3-triazoles 7a-i were designed and synthesized by the one-pot reaction of diaryl-(1-aryl-5-methyl-1H-1,2,3-triazol-4-yl)methanol compounds with 1H-imidazole. The new compounds 7a-i were ch

Primary discovery of 1-aryl-5-substituted-1H-1,2,3-triazole-4-carboxamides as promising antimicrobial agents

Three series of novel 1H-1,2,3-triazole-4-carboxamides: 1-aryl-5-alkyl/aryl-1H-1,2,3-triazole-4-carboxamides, 1-aryl-5-amino-1H-1,2,3-triazole-4-carboxamides and 1,2,3-triazolo[1,5-a]quinazoline-3-carboxamides were synthesized via base-mediated click azide reactions. Compounds were evaluated for their antimicrobial activities against primary pathogens: Gram-positive and Gram-negative bacterial strains Escherichia coli, Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, as well as fungal strain Cryptococcus neoformans var. grubii and Candida albicans. Compounds exhibiting moderate to good activities were selected for SAR analysis. Several 5-methyl-1H-1,2,3-triazole-4-carboxamides 4d, 4l, 4r, showed potent antibacterial effect against S. aureus. On the contrary, 5-amino-1H-1,2,3-triazole-4-carboxamide 8b and [1,2,3]triazolo[1,5-a]quinazoline-3-carboxamide 9a were active against pathogenic yeast C. albicans. Thus, compound 4l under 1 μM demonstrated 50% growth inhibition against S. aureus. At the same concentration, the compound 9a killed approx. 40% of C. albicans cells. In general, these compounds demonstrated selective action and no significant impact on the viability of human keratinocytes of HaCaT line.

Convenient and efficient synthesis of disubstituted piperazine derivatives by catalyst-free, atom-economical and tricomponent domino reactions

One-pot, atom-economical, catalyst-free and tri-component domino reactions are applied to the diversity-oriented synthesis (DOS) of disubstituted piperazine derivatives under mild conditions with moderate to high yields. This protocol exhibits potential a

The synthesis of some new (S)-1-aryl-N-(1-hydroxy-3-phenylpropan-2-yl)-5- methyl-1H-1,2,3-triazole-4-carboxamide

Some new (S)-1-aryl-N-(1-hydroxy-3-phenylpropan-2-yl)-5-methyl-1 H-1,2,3-triazole-4-carboxamides 4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h, 4i, 4j have been synthesized and established by 1H and 13C NMR, IR, MS spectra, CHN analyses, and x-ray

Synthesis and characterization of some new 1,2,4-triazines containing 1,2,3-triazole

A series of 3-(1 -aryl-1 H-1,2,3-triazol-4-yl)-6-phenyl-1,2,4-triazines were synthesized by the reaction of 1-aryl-1tf-1,2,3-triazole-4-carbohydrazide with 2-bromo-1- phenylethanone and sodium acetate in refluxed EtOH and AcOH. Their structures were chara

Synthesis of some novel 3,6-bis(1,2,3-triazolyl)-s-triazolo[3,4-b]-1,3,4- thiadiazole derivatives

The cyclization of 1-amino-2-mercapto-5-[1-(4-ethoxyphenyl)-5-methyl-1,2,3- triazol-4-yl]-1,3,4-triazole which was synthesized from p-ethoxyaniline with various triazole acid in absolute phosphorus oxychloride yields 3,6-bis(1,2,3-triazolyl)-s-triazolo[3,