33799-96-1

Basic information

• Product Name: N-(4-FLUOROBENZOYL)-PHENYL-ETHYLAMINE
• Synonyms: N-(4-FLUOROBENZOYL)-PHENYL-ETHYLAMINE;4-Fluoro-N-phenethylbenzamide
• CAS NO: 33799-96-1
• Molecular Formula: C₁₅H₁₄FNO
• Molecular Weight: 243.28
• Mol File: 33799-96-1.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 416.2°Cat760mmHg
• Flash Point: 205.5°C
• Appearance: /
• Density: 1.151g/cm³
• Vapor Pressure: 3.91E-07mmHg at 25°C
• Refractive Index: 1.566
• CAS DataBase Reference: N-(4-FLUOROBENZOYL)-PHENYL-ETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-FLUOROBENZOYL)-PHENYL-ETHYLAMINE(33799-96-1)
• EPA Substance Registry System: N-(4-FLUOROBENZOYL)-PHENYL-ETHYLAMINE(33799-96-1)

Safety Data

• Hazardous Substances Data: 33799-96-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H14FNO/c16-14-8-6-13(7-9-14)15(18)17-11-10-12-4-2-1-3-5-12/h1-9H,10-11H2,(H,17,18)

Upstream product

• 64-04-0 phenethylamine 
• 459-57-4 4-fluorobenzaldehyde 
• 1590389-14-2 potassium trifluoro(4-fluorobenzoyl)borate 
• 2205-01-8 N-methoxyphenethylamine 
• 69424-54-0 O-benzoyl-N-phenethylhydroxylamine 
• 1415337-72-2 O-(4-nitrophenyl)-N-phenethylhydroxylamine 
• 1590361-12-8 O-benzoyl-(3-phenylpropyl)hydroxylamine 
• 1590361-11-7 O-diethylcarbamoyl-N-phenethylhydroxylamine 
• 1590361-10-6 O-phenylcarbamoyl-N-phenethylhydroxylamine 
• 1590361-09-3 O-methoxycarbonyl-N-phenethylhydroxylamine 
• 1590361-08-2 O-benzyloxycarbonyl-N-phenethylhydroxylamine 
• 1590361-20-8 N-tert-butoxycarbonyl-O-diethylcarbamoyl-N-phenethylhydroxylamine 
• 1590361-19-5 N-tert-butoxycarbonyl-O-phenylcarbamoyl-N-phenethylhydroxylamine 
• 1590361-18-4 N-tert-butoxycarbonyl-O-methoxycarbonyl-N-phenethylhydroxylamine 

Relevant articles and documents

Visible Light-Driven Efficient Synthesis of Amides from Alcohols using Cu?N?TiO2 Heterogeneous Photocatalyst

Amides were synthesized from alcohols and amines in high yields using an in situ generated active ester of N-hydroxyimide with our developed Cu?N?TiO2 catalyst at room temperature using oxygen as a sole oxidant under visible light. The catalyst can be easily prepared, robust, and recycled four times without a considerable change in catalytic activity. This developed protocol applies to a wide substrate scope and has good functional group tolerance. The application of this amidation reaction has been successfully demonstrated for the synthesis of moclobemide, an antidepressant drug, and an analog of the itopride drug on a gram scale.

Discovery of quinuclidine modulators of cellular progranulin

Phenotypic screening of an annotated small molecule library identified the quinuclidine tetrahydroisoquinoline solifenacin (1) as a robust enhancer of progranulin secretion with single digit micromolar potency in a murine microglial (BV-2) cell line. Subsequent SAR development led to the identification of 29 with a 38-fold decrease in muscarinic receptor antagonist activity and a 10-fold improvement in BV-2 potency.

PROGRANULIN MODULATORS AND METHODS OF USING THE SAME

Provided herein are compounds that modulate progranulin and methods of using the compounds in progranulin-associated disorders, such as Frontotemporal dementia (FTD).