344261-84-3

Basic information

• Product Name: 1-(4-fluorophenyl)-3,4-dihydroisoquinoline
• Synonyms: 1-(4-fluorophenyl)-3,4-dihydroisoquinoline
• CAS NO: 344261-84-3
• Molecular Weight: 225.265
• Mol File: 344261-84-3.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 1-(4-fluorophenyl)-3,4-dihydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluorophenyl)-3,4-dihydroisoquinoline(344261-84-3)
• EPA Substance Registry System: 1-(4-fluorophenyl)-3,4-dihydroisoquinoline(344261-84-3)

Safety Data

• Hazardous Substances Data: 344261-84-3(Hazardous Substances Data)

Upstream product

• 33799-96-1 N-(2-phenylethyl)-4-fluorobenzamide 
• 403-43-0 4-fluorobenzoyl chloride 
• 64-04-0 phenethylamine 
• 14157-05-2 1-(methylsulfanyl)-3,4-dihydroisoquinoline 
• 1765-93-1 4-fluoroboronic acid 
• 120086-34-2 1-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline 
• 456-22-4 4-Fluorobenzoic acid 
• 60-12-8 2-phenylethanol 
• 1194-02-1 4-fluorobenzonitrile 
• 1196-38-9 3,4-dihydroisoquinolin-1(2H)-one 
• 352-13-6 4-flourophenylmagnesium bromide 

Downstream Products

• 1587705-05-2 C₇₀H₄₂FNO₂ 
• 1587705-04-1 C₅₄H₃₄FNO₂ 
• 1587705-03-0 C₃₈H₂₆FNO₂ 
• 120086-34-2 1-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline 
• 1381986-38-4 (R)-1-(4-fluorophenyl)-2-tosyl-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Discovery of quinuclidine modulators of cellular progranulin

Phenotypic screening of an annotated small molecule library identified the quinuclidine tetrahydroisoquinoline solifenacin (1) as a robust enhancer of progranulin secretion with single digit micromolar potency in a murine microglial (BV-2) cell line. Subsequent SAR development led to the identification of 29 with a 38-fold decrease in muscarinic receptor antagonist activity and a 10-fold improvement in BV-2 potency.

Diprotonative stabilization of ring-opened carbocationic intermediates: conversion of tetrahydroisoquinoline to triarylmethanes

Superacid-promoted conversion of tetrahydroisoquinolines to triarylmethanes via tandem reactions of C-N bond scission, Friedel-Crafts alkylation, C-O bond scission, and electrophilic aromatic amidation was developed. Dication formation was important for stabilizing the ring-opened carbocationic intermediate, which is a new role for diprotonation in reaction mechanisms. This journal is

A Method for Bischler-Napieralski-Type Synthesis of 3,4-Dihydroisoquinolines

A new method for the Bischler-Napieralski-type synthesis of 3,4-dihydroisoquinolines was developed by a Tf2O-promoted tandem annulation from phenylethanols and nitriles. Its success was mainly due to the fact that a phenonium ion was formed in the process and practically functioned as a stable and reactive primary phenylethyl carbocation.