3380-30-1

Basic information

• Product Name: HYDROXYDICHLORODIPHENYL ETHER
• Synonyms: HYDROXYDICHLORODIPHENYL ETHER;2-Hydroxy-4,4'-dichlordiphenyl ether;Phenol, 5-chloro-2-(4-chlorophenoxy)-;2-Hydroxy-4,4'-dichlorodiphenyl ether;4,4-DICHLORO-2-HYDROXYDIPHENYL ETHER;5-Chloro-2-(p-chlorophenoxy)phenol
• CAS NO: 3380-30-1
• Molecular Formula: C₁₂H₈Cl₂O₂
• Molecular Weight: 255.09672
• EINECS: 429-290-0
• Mol File: 3380-30-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 78-79 °C
• Boiling Point: 333.1°Cat760mmHg
• Flash Point: 155.2°C
• Appearance: /
• Density: 1.398g/cm³
• Vapor Pressure: 7.23E-05mmHg at 25°C
• Refractive Index: 1.623
• PKA: 8.07±0.35(Predicted)
• Water Solubility: 19.5mg/L at 20℃
• CAS DataBase Reference: HYDROXYDICHLORODIPHENYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: HYDROXYDICHLORODIPHENYL ETHER(3380-30-1)
• EPA Substance Registry System: HYDROXYDICHLORODIPHENYL ETHER(3380-30-1)

Safety Data

• Hazardous Substances Data: 3380-30-1(Hazardous Substances Data)

Usage

General Description

Hydroxydichlorodiphenyl ether, also known as OH-PCB, is a chemical compound that belongs to the group of polychlorinated biphenyls (PCBs). It is a byproduct of the metabolism of PCBs in the environment and has been found to have toxic effects on both humans and wildlife. OH-PCB has been shown to interfere with hormone signaling and disrupt normal endocrine function, leading to a range of health problems such as reproductive and developmental issues, immune system suppression, and increased risk of cancer. Due to its persistence in the environment and potential for bioaccumulation, OH-PCB poses a significant threat to ecosystems and human health, and measures to reduce its exposure and production are necessary to mitigate its harmful effects.

InChI:InChI=1/C12H8Cl2O2/c13-8-1-4-10(5-2-8)16-12-6-3-9(14)7-11(12)15/h1-7,15H

Upstream product

• 3380-53-8 Acetic acid 5-chloro-2-(4-chloro-phenoxy)-phenyl ester 
• 135-12-6 4-chloro-1-(4-chlorophenoxy)-2-nitrobenzene 
• 89-61-2 2,5-dichloronitrobenzene 
• 106-48-9 4-chloro-phenol 

Downstream Products

• 26011-95-0 Thiocarbonic acid O,O-bis-[5-chloro-2-(4-chloro-phenoxy)-phenyl] ester 
• 28513-17-9 (2,4-Dichloro-phenyl)-carbamic acid 5-chloro-2-(4-chloro-phenoxy)-phenyl ester 
• 28386-35-8 (3-Bromo-phenyl)-carbamic acid 5-chloro-2-(4-chloro-phenoxy)-phenyl ester 
• 26011-85-8 Thiocarbonic acid O-[5-chloro-2-(4-chloro-phenoxy)-phenyl] ester O-(4-octyl-phenyl) ester 
• 26011-89-2 Thiocarbonic acid O-[5-chloro-2-(4-chloro-phenoxy)-phenyl] ester O-(4-nonyl-phenyl) ester 
• 28386-36-9 (4-Chloro-phenyl)-thiocarbamic acid O-[5-chloro-2-(4-chloro-phenoxy)-phenyl] ester 
• 28386-43-8 p-Tolyl-carbamic acid 5-chloro-2-(4-chloro-phenoxy)-phenyl ester 
• 28469-05-8 (4-Fluoro-phenyl)-carbamic acid 5-chloro-2-(4-chloro-phenoxy)-phenyl ester 
• 28386-46-1 (3,5-Dimethyl-phenyl)-thiocarbamic acid O-[5-chloro-2-(4-chloro-phenoxy)-phenyl] ester 
• 28386-40-5 (4-Chloro-3-trifluoromethyl-phenyl)-carbamic acid 5-chloro-2-(4-chloro-phenoxy)-phenyl ester 
• 28386-38-1 (3,4-Dichloro-phenyl)-carbamic acid 5-chloro-2-(4-chloro-phenoxy)-phenyl ester 
• 28386-41-6 (4-Chloro-3-trifluoromethyl-phenyl)-thiocarbamic acid O-[5-chloro-2-(4-chloro-phenoxy)-phenyl] ester 
• 28386-39-2 (3-Trifluoromethyl-phenyl)-carbamic acid 5-chloro-2-(4-chloro-phenoxy)-phenyl ester 
• 28386-47-2 (3-Methoxy-phenyl)-carbamic acid 5-chloro-2-(4-chloro-phenoxy)-phenyl ester 

Relevant articles and documents

Method for preparing diclosan through Baeyer-Villiger oxidation

The invention provides a method for preparing diclosan by using urea peroxide as an oxidizing agent. Particularly, the method comprises the following steps: (1) oxidizing 5-chloro-2-(4-chloro-phenoxy)-acetophenone in an inert solvent by using urea peroxide as an oxidizing agent to obtain an intermediate I; and (2) hydrolyzing the intermediate I to obtain the diclosan. The method is safe in production process, mild in reaction and suitable for industrial production.

Process for the preparation of halogenated hydroxydiphenyl compounds

There is described a process for the preparation of halogenated hydroxydiphenyl compounds of formula (1) by acylation of a halogenated benzene compound (first stage), etherification of the acylated compound with a halogenated phenol compound, which is not further substituted in the ortho-position (second stage), oxidation of the etherified compound (third stage) and hydrolysis of the oxidized compound in a fourth stage, wherein the reaction of the second stage is carried out in the presence of K2CO3 and any desired copper catalyst, where K2CO3 is used in a concentration of from 0.5 to 30 mol, based on the phenol compound employed of formula (6), according to the reaction scheme (I) in which R1 and R2 independently of one another are F, Cl or Br; R3 and R4 independently of one another are hydrogen; or C1-C4alkyl; m is 1 to 3; and n is 1 or 2. The compounds of formula (1) are used for protecting organic materials and articles from microorganisms.