135-12-6

Basic information

• Product Name: 4-Chloro-1-(4-chlorophenoxy)-2-nitrobenzene
• Synonyms: 4-chloro-1-(4-chlorophenoxy)-2-nitrobenzene;4,4'-Dichloro-2-nitrodiphenyl ether;2-Nitro-4,4-dichloro-diphenyl ether;4-CHLOROPHENYL 4-CHLORO-2-NITROPHENYL ETHER
• CAS NO: 135-12-6
• Molecular Formula: C₁₂H₇Cl₂NO₃
• Molecular Weight: 284.09
• EINECS: 205-176-4
• Mol File: 135-12-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 363.01 °C at 760 mmHg
• Flash Point: 173.342 °C
• Appearance: /
• Density: 1.4923 (rough estimate)
• Vapor Pressure: 3.88E-05mmHg at 25°C
• Refractive Index: 1.6140 (estimate)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Chloro-1-(4-chlorophenoxy)-2-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-1-(4-chlorophenoxy)-2-nitrobenzene(135-12-6)
• EPA Substance Registry System: 4-Chloro-1-(4-chlorophenoxy)-2-nitrobenzene(135-12-6)

Safety Data

• Hazardous Substances Data: 135-12-6(Hazardous Substances Data)

Usage

Chemical Properties

yellow powder

InChI:InChI=1/C12H7Cl2NO3/c13-8-1-4-10(5-2-8)18-12-6-3-9(14)7-11(12)15(16)17/h1-7H

Upstream product

• 106-48-9 4-chloro-phenol 
• 89-61-2 2,5-dichloronitrobenzene 
• 2444-89-5 4,4'-dichlorodiphenyl ether 
• 7664-93-9 sulfuric acid 
• 64-19-7 acetic acid 
• 100-00-5 4-chlorobenzonitrile 
• 35535-81-0 sodium 2-chlorophenoxide 
• 106-46-7 para-dichlorobenzene 
• 1121-74-0 potassium 4-chlorophenoxide 

Downstream Products

• 1286264-43-4 N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N²-{2-[methy(phenyl)amino]-2-oxoethyl}-N¹-(2-pyrrolidin-1-ylethyl)glycinamide 
• 1286264-03-6 N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N²-{2-[2,3-dihydro-1H-inden-2-yl(methyl)amino]-2-oxoethyl}-N¹-(2-pyrrolidin-1-ylethyl)glycinamide 
• 1286264-62-7 N²-{2-[(1-acetylpiperidin-4-yl)(methyl)amino]-2-oxoethyl}-N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N¹-(2-pyrrolidin-1-ylethyl)glycinamide 
• 1286264-63-8 N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N²-{2-{methyl[1-(methylsulfonyl)piperidin-4-yl]amino}-2-oxoethyl}-N¹-(2-pyrrolidin-1-ylethyl)glycinamide 
• 1286264-65-0 N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N²-{2-{[1-(methoxycarbonyl)piperidin-4-yl](methyl)amino}-2-oxoethyl}-N¹-(2-pyrrolidin-1-ylethyl)glycinamide 
• 1286263-69-1 N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N²-{2-[1,3-dihydro-2H-isoindol-2-yl(methyl)amino]-2-oxoethyl}-N¹-(2-pyrrolidin-1-ylethyl)glycinamide 

Relevant articles and documents

Preparation method of active bactericide 4,4'-dichloro-2-hydroxyl diphenyl ether

The invention discloses a preparation method of an active bactericide 4,4'-dichloro-2-hydroxyl diphenyl ether. The preparation method comprises the following steps: preparing phenol metal salts from p-chlorophenol under the effect of an alkali solution; carrying out condensation reactions, nitro reduction reactions, and diazotization hydrolysis reactions between phenol metal salts and 2,5-dichloronitrobenzene; extracting the reaction product by a solvent; and purifying the extract by vacuum distillation to obtain the high quality active bactericide. The operation is convenient, the production cost is low, and the product purity is high. The bactericide can effectively kill or inhibit gram positive bacteria and gram negative bacteria. The bactericide can be easily compounded with a negative ion surfactant, a nonionic surfactant, an amphoteric surfactant, and a positive ion surfactant.

Discovery and structural analyses of S-adenosyl-l-homocysteine hydrolase inhibitors based on non-adenosine analogs

Optimization of a new series of S-adenosyl-l-homocysteine hydrolase (AdoHcyase) inhibitors based on non-adenosine analogs led to very potent compounds 14n, 18a, and 18b with IC50 values of 13 ± 3, 5.0 ± 2.0, and 8.5 ± 3.1 nM, respectively. An X-ray crystal structure of AdoHcyase with NAD+ and 18a showed a novel open form co-crystal structure. 18a in the co-crystals formed intramolecular eight membered ring hydrogen bond formations. A single crystal X-ray structure of 14n also showed an intramolecular eight-membered ring hydrogen bond interaction.

Process for preparing nitrodiphenyl (thio) ethers

Nitrodiphenyl(thio) ethers in which the nitro group is in the ortho- or para-position with respect to the ether oxygen or ether sulphur can be prepared from halonitrobenzones in which the nitro group is in the ortho- or para-position with respect to the halogen and, alkali metal (thio)phenolates in liquid ammonia, the reaction being carried out under pressure and at a temperature from -30° C. to +140° C. and the ammonia being separated off after the reaction is completed.