33802-05-0

Basic information

• Product Name: Cyclohexanone, 2-(2,2,2-trichloro-1-hydroxyethyl)-
• CAS NO: 33802-05-0
• Molecular Formula: C8H11Cl3O2
• Molecular Weight: 245.533
• Mol File: 33802-05-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Cyclohexanone, 2-(2,2,2-trichloro-1-hydroxyethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanone, 2-(2,2,2-trichloro-1-hydroxyethyl)-(33802-05-0)
• EPA Substance Registry System: Cyclohexanone, 2-(2,2,2-trichloro-1-hydroxyethyl)-(33802-05-0)

Safety Data

• Hazardous Substances Data: 33802-05-0(Hazardous Substances Data)

Upstream product

• 302-17-0 chloral hydrate 
• 108-94-1 cyclohexanone 
• 108-24-7 acetic anhydride 
• 6651-36-1 1-(Trimethylsilyloxy)cyclohexene 
• 75-87-6 chloral 
• 704905-48-6 (5'S)-spiro[cyclohexane-1,2'-3-oxa-1-azabicyclo[3.3.0]octan]-4'-one 
• 64340-79-0 1-(dimethylsilyloxy)cyclohexene 
• 670-80-4 4-cyclohexen-1-ylmorpholine 

Downstream Products

• 103659-53-6 (Z)-2-(2-chlorovinyl)cyclohexanone 

Relevant articles and documents

Highly enantioselective aldol reactions using a tropos dibenz[c,e]azepine organocatalyst

The four-step synthesis of a chiral primary tertiary diamine salt, possessing a tropos dibenz[c,e]azepine ring is described. It is shown that 3.5-5 mol % of this salt is capable of promoting highly enantioselective crossed-aldol reactions between cyclohexanone and a series of aromatic aldehydes. In all cases, the aldol reactions proceed with high diastereoselectivity for the anti-aldol product. The outcome of crossed-aldol reactions involving other cyclic ketones and acyclic ketones are also described. All examples involving cyclic ketones result in selectivity for the anti-aldol products, whereas acyclic ketones were found to favour the syn-aldol products. A discussion on the role of the chiral primary tertiary diamine salt in the catalysis of the aldol reactions is also presented.

Asymmetric direct aldol reaction assisted by water and a proline-derived tetrazole catalyst.

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