33809-91-5

Upstream product

• 4856-97-7 2-(Hydroxymethyl)benzimidazole 
• 108-24-7 acetic anhydride 
• 449796-13-8 N-acetoxy-2-(acetoxymethyl)benzimidazole 

Downstream Products

• 944061-83-0 C₁₇H₁₆N₂O₂ 
• 500149-05-3 (1-(2,4-dichlorobenzyl)-1H-benzo[d]imidazol-2-yl)methanol 
• 63633-05-6 1-vinyl-2-hydroxymethylbenzimidazole 
• 118482-08-9 1-vinylbenzimidazole-2-carboxaldehyde 
• 6646-70-4 (1-benzyl-1H-benzo[d]imidazol-2-yl)methanol 
• 7467-35-8 (1-methyl-1H-benzimidazol-2-yl)methanol 

Relevant academic research and scientific papers

Synthesis, cytotoxicity, and DNA interactions of new cisplatin analogues containing substituted benzimidazole ligands

Six new platinum(II) complexes with 1-H or methyl-2-chloromethyl or acetoxymethyl or 2′-hydroxyethyl- benzimidazole carrier ligands were synthesized and evaluated for their reactivity against model nucleophile I -, cellular uptake, and in vitro antiproliferative activities against the human MCF-7 breast and HeLa cervix cancer cell lines. The effect of the compounds on pBR322 plasmid DNA was studied by gel electrophoretic mobility measurements. Flow cytometric analysis was also carried out to study the effect of representative compounds 1 and 2, bearing 2-chloromethyl or -acetoxymethylbenzimidazole carrier ligands, on the cell cycle distribution of MCF-7 and HeLa cells, respectively. In general, it was found that Pt(II) complexes were less cytotoxic than cisplatin and were comparable to carboplatin. The results of the plasmid DNA interaction and the restriction studies suggest that changing the chemical structure of the benzimidazole ligands may modulate DNA binding mode and the sequence selectivity. Compounds 1 and 2 had no significant effect on the cell cycle profile of the cells used. However, compound 2 induced a significant increase in the SubG1 cell population at a concentration of 20 μM.

Alternate method for the synthesis of N-alkyl/aralkyl-2-(α-hydroxy alkyl/aralkyl)benzimidazoles via regiospecific acetylation

Acetylation of 1H-2-(α-hydroxyalkyl/aryl)benzimidazoles 2 with Ac2O results in the regiospecific formation of O-acetoxy derivative 3, which on alkylation with alkylating agents in nonaqueous media under phase-transfer catalytic conditions affords N-alkyl

6-beta(substituted)-(S)-hydroxymethylpenicillanic acids and derivatives thereof

Antibacterial penicillins of the formula STR1 or a pharmaceutically acceptable salt thereof wherein R1 is a heterocyclic group and R is hydrogen, the residue of certian carboxy protecting groups or the residue of an ester group readily hydrolyzable in vivo having activity against resistant organisms.