33828-92-1Relevant academic research and scientific papers
A General Strategy to Enhance Donor-Acceptor Molecules Using Solvent-Excluding Substituents
Asbury, John B.,Hoelzel, Conner A.,Hu, Hang,Jung, Kwan Ho,Karim, Basel A.,Li, Xiaosong,Liu, Yu,Munson, Kyle T.,Wolstenholme, Charles H.,Yennawar, Hemant P.,Zhang, Han,Zhang, Xin
supporting information, p. 4785 - 4792 (2020/02/11)
While organic donor-acceptor (D-A) molecules are widely employed in multiple areas, the application of more D-A molecules could be limited because of an inherent polarity sensitivity that inhibits photochemical processes. Presented here is a facile chemical modification to attenuate solvent-dependent mechanisms of excited-state quenching through addition of a β-carbonyl-based polar substituent. The results reveal a mechanism wherein the β-carbonyl substituent creates a structural buffer between the donor and the surrounding solvent. Through computational and experimental analyses, it is demonstrated that the β-carbonyl simultaneously attenuates two distinct solvent-dependent quenching mechanisms. Using the β-carbonyl substituent, improvements in the photophysical properties of commonly used D-A fluorophores and their enhanced performance in biological imaging are shown.
3-[6-(2-Dimethylamino-1-imidazol-1-yl-butyl)-naphthalen-2-yloxy]-2,2-dimethyl-propionic acid as a highly potent and selective retinoic acid metabolic blocking agent
Mulvihill, Mark J.,Kan, Julie L.C.,Cooke, Andrew,Bhagwat, Shripad,Beck, Patricia,Bittner, Mark,Cesario, Cara,Keane, David,Lazarescu, Viorica,Nigro, Anthony,Nillson, Christy,Panicker, Bijoy,Smith, Vanessa,Srebernak, Mary,Sun, Feng-Lei,O'Connor, Matthew,Russo, Suzanne,Fischetti, Gia,Vrkljan, Michael,Winski, Shannon,Castelhano, Arlindo L.,Emerson, David,Gibson, Neil W.
, p. 2729 - 2733 (2007/10/03)
3-[6-(2-Dimethylamino-1-imidazol-1-yl-butyl)-naphthalen-2-yloxy]-2,2-dimethyl-propionic acid and analogs were designed and synthesized as highly potent and selective CYP26 inhibitors, serving as retinoic acid metabolic blocking agents (RAMBAs), with demonstrated in vivo efficacy to increase the half-life of exogenous atRA.
Spiro-pyranic compounds endowed with photochromic characteristics
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, (2008/06/13)
Photochromic compounds belonging to the class of spiro-pyrans, having the general formula (I): STR1
Spiro-pyranic compounds endowed with photochromic characteristics
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, (2008/06/13)
Photochromic compounds belonging to the class of spiro-pyrans, having the general formula (I):
Intermediates for preparing optically active carboxylic acids
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, (2008/06/13)
A process is described for preparing optically active alpha-arylalkanoic acids consisting of rearranging an optically active ketal of formula STR1 in which the substituents have the meaning given in the description of the invention.
