33828-99-8Relevant academic research and scientific papers
Synthesis of 1,3-diaryl-spiro[azetidine-2,3′-indoline]-2′,4-diones: Via the Staudinger reaction: Cis - Or trans -diastereoselectivity with different addition modes
Beloglazkina, Elena,Filatov, Vadim,Kukushkin, Maksim,Kuznetsova, Juliana,Majouga, Alexander,Skvortsov, Dmitry,Tafeenko, Viktor,Zyk, Nikolay
, p. 14122 - 14133 (2020)
A new synthetic approach for realizing biologically relevant bis-aryl spiro[azetidine-2,3′-indoline]-2′,4-diones was developed based on Staudinger ketene-imine cycloaddition through the one-pot reaction of substituted acetic acids and Schiff bases in the presence of oxalyl chloride and an organic base. A series of [azetidine-2,3′-indoline]-2′,4-diones were synthesized using this method. For comparison, the same compounds were obtained using a known technique, where ketene is generated from pre-synthesized acyl chloride. It was shown that the use of oxalyl chloride for ketene generation in the one-pot reaction at room temperature allows for the reversal of the diastereoselectivity of spiro-lactam formation, unlike previously described procedures.
On antimicrobial activity of 3'-phenylspiro[3H-indole-3,2'-thiazolidine]-2,4' (1H)-diones
Diurno,Mazzoni,Piscopo,Bolognese
, p. 435 - 441 (2007/10/02)
3'-substituted phenylspiro[3H-indole-3,2'-thiazolidine]-2,4' (1H)-diones (1-15), tested toward Gram-positive, Gram-negative bacteria and Fungi, showed a significant activity against Gram-positive bacteria.
