338392-48-6

Usage

Uses

Used in Organic Synthesis:
[1-(Bromomethyl)cyclopropyl]acetonitrile is used as a reagent for the introduction of the cyclopropylmethyl group into various organic molecules. Its application is based on the high reactivity and versatility of the bromomethyl group, which allows for a wide range of synthetic applications in the creation of complex organic compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, [1-(Bromomethyl)cyclopropyl]acetonitrile is used as an intermediate for the synthesis of various pharmaceutical compounds. [1-(Bromomethyl)cyclopropyl]acetonitrile's reactivity and structural features make it a useful building block for developing new drugs with specific therapeutic properties.
Used in Chemical Research:
[1-(Bromomethyl)cyclopropyl]acetonitrile is also utilized in chemical research as a model compound to study the effects of different functional groups on the reactivity and properties of organic molecules. This helps researchers understand the underlying chemical reactions and mechanisms, which can be applied to the development of new synthetic methods and the design of novel compounds.

Upstream product

• 152922-71-9 1-(hydroxymethyl)cyclopropaneacetonitrile 
• 855473-50-6 1-bromomethylcyclopropyl acetic acid methyl ester 
• 39590-81-3 [1-(hydroxymethyl)cyclopropyl]methanol 
• 142148-13-8 1-hydroxymethylcyclopropylacetic acid methyl ester 

Relevant academic research and scientific papers

Montelukast side chain intermediate and preparing method thereof

The invention belongs to the field of medical chemistry, and particularly relates to a montelukast side chain intermediate and a preparing method thereof. A provided intermediate compound is 6-halogenated methyl-5,7-dioxaspiro[2,5] octane, wherein 1,1-cyclopropyl dimethyl carbinol serving as a starting material and 2-halogeno-1,1-dimethoxyethane are subjected to a transacetalation reaction under solid acid catalysis to obtain 6-halogenated methyl-5,7-dioxaspiro[2,5] octane, the intermediate is treated with organic alkali and then hydrolyzed with a water solution containing acetic acid to obtain monoacetylated protected diol. The problems that monoacetylated protected diol is poor in selectivity, and diol loss is serious are solved, the availability of the raw materials is improved, and the montelukast side chain intermediate can be synthesized economically and conveniently.

NOVEL PROCESS FOR PREPARING 1-(MERCAPTOMETHYL) CYCLOPROPANEACETIC ACID, A USEFUL INTERMEDIATE IN THE PREPARATION OF MONTELUKAST AND SALTS THEREOF

The present invention provides a novel montelukast intermediate and a simple and straightforward process for preparing it. According to the present invention, by using this intermediate and the process, essentially as described herein, montelukast acid and salts thereof are obtained.

Process for preparation of [1-(mercaptomethyl)cyclopropyl]acetic acid and related derivatives

The present invention provides a novel process for preparing [1-(mercaptomethyl)cyclopropyl]acetic acid with high purity and related derivatives.

Substituted 5-benzyl-2,4-diaminopyrimidines

The invention relates to substituted 5-benzyl-2,4-diaminopyrimidines of general formula (A) wherein R1is C2-C3 alkyl an R2is heterocyclyl, phenyl or naphthyl, bonded by one of its C-atoms and R3is C2-C6 alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, heterocyclylalkyl, alkylsulfonyl, cycloalkylsulfonyl, cycloalkylalkylsulfamoyl, heterocyclysylfonyl, heterocyclylalkylsulfonyl or dialkylsulfamoyl; wherein alkyl, cycloalkyl and alyenyl can carry up to 6 carbon atoms alone or in compositions and can carry up to 6 ring members heterocyclically, alone, or in compositions and the groups R2and R3can be substituted; and to acid addition salts of compounds. The invention also relates to a method for producing the above 5-benzyl-2,4-diaminopyrimidines, to the intermediate. products that are produced, to corresponding medicaments and to the use of 5-benzyl-2,4-diaminopyrimidines as medicinal preparations. The products have antibiotic properties and are useful for combating or preventing infectious diseases.