152922-71-9

Basic information

• Product Name: 1-(Hydroxymethyl)cyclopropaneacetonitrile
• Synonyms: [1-(HYDROXYMETHYL)CYCLOPROPYL]ACETONITRILE;2-[1-(HYDROXYMETHYL)-CYCLOPROPYL]-ACETONITRILE;Montelukast Intermediates;1-Hydroxymethyl Cyclopropyl Acetonitrile (Montelukast Intermediates);[1-(Hydroxymethyl)cyclopropyl]acetonitrile 97%;1-(Hydroxymethyl)cyclopropaneacetonitrile;1,1-cyclopropane dimethanol cylic sufite;1-(Hydroxymethyl)cycolpropane acetonitrile
• CAS NO: 152922-71-9
• Molecular Formula: C₆H₉NO
• Molecular Weight: 111.14
• EINECS: 1312995-182-4
• Product Categories: Ring Systems
• Mol File: 152922-71-9.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 245.1 °C at 760mmHg
• Flash Point: 102.1 °C
• Appearance: white or almost white power
• Density: 1.098 g/cm³
• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.489
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Methanol (Slightly)
• PKA: 15.10±0.10(Predicted)
• CAS DataBase Reference: 1-(Hydroxymethyl)cyclopropaneacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(Hydroxymethyl)cyclopropaneacetonitrile(152922-71-9)
• EPA Substance Registry System: 1-(Hydroxymethyl)cyclopropaneacetonitrile(152922-71-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 152922-71-9(Hazardous Substances Data)

Usage

Uses

1-(Hydroxymethyl)cyclopropaneacetonitrile is a reactant used in the preparation of benzothiazoles and thiazoles substituted benzyl alcohols as potent LTD4 antagonists.

InChI:InChI=1/C6H9NO/c7-4-3-6(5-8)1-2-6/h8H,1-3,5H2

Upstream product

• 39590-81-3 [1-(hydroxymethyl)cyclopropyl]methanol 
• 143-33-9 sodium cyanide 
• 4773-13-1 diisopropyl sulfite 
• 3580-97-0 3-bromo-2,2-bis(bromomethyl)propyl acetate 
• 1522-92-5 2,2-bis(bromomethyl)-3-bromo-propan-1-ol 
• 115-77-5 Pentaerythritol 
• 142148-13-8 1-hydroxymethylcyclopropylacetic acid methyl ester 
• 855473-50-6 1-bromomethylcyclopropyl acetic acid methyl ester 
• 773837-37-9 sodium cyanide 
• 89729-09-9 5,7-dioxa-6-thia-spiro[2.5]octane 6-oxide 
• 90087-10-8 [1-(cyanomethyl) cyclopropyl]methyl acetate 
• 869066-76-2 1-(p-methoxybenzoyloxymethyl)cyclopropane-1-acetonitrile 
• 4437-68-7 5,7-dioxa-spiro[2.5]octan-6-one 
• 13435-20-6 tetraethylammoniumcyanide 

Downstream Products

• 869066-83-1 2‐[1‐(hydroxymethyl)cyclopropyl]acetic acid 
• 162515-68-6 1-(sulfanylmethyl)cyclopropaneacetic acid 
• 1087347-36-1 tert-butyl (3R,4S)-3-{[[3-({1-[2-(benzyloxy)-2-oxoethyl]cyclopropyl}methoxy)-5-(3-methoxypropyl)benzyl](cyclopropyl)amino]carbonyl}-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate 
• 1087347-37-2 tert-butyl (3R,4S)-3-{[(cyclopropyl)(3-(3-methoxypropyl)-5-{[1-(2H-tetrazol-5-ylmethyl)cyclopropyl]methoxy}benzyl)amino]carbonyl}-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate 
• 1087347-35-0 (1-{[3-{[[((3R,4S)-1-(tert-butoxycarbonyl)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl](cyclopropyl)amino]methyl}-5-(3-methoxypropyl)phenoxy]methyl}cyclopropyl)acetic acid 
• 1087347-34-9 tert-butyl (3R,4S)-3-({(cyclopropyl)[3-{[1-(2-methoxy-2-oxoethyl)cyclopropyl]methoxy}-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-{4-[2-(2.,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate 
• 1026787-28-9 tert-butyl (3R,4S)-3-(((3-((1-(cyanomethyl)cyclopropyl)methoxy)-5-(3-methoxypropyl)-benzyl)(cyclopropyl)amino)carbonyl)-4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)-piperidine-1-carboxylate 
• 142148-13-8 1-hydroxymethylcyclopropylacetic acid methyl ester 
• 338392-48-6 2-(1-(bromomethyl)cyclopropyl)acetonitrile 

Relevant articles and documents

Preparation method of 1-hydroxymethylcyclopropyl acetonitrile

The present invention relates to a method for preparing 1-hydroxymethylcyclopropyl acetonitrile, which belongs to the field of pharmaceutical intermediate synthesis technology. The present invention takes pentaerythritol as raw material, after bromination reaction to give tribromo neoamyl alcohol, and then by acetylation reaction to give 3-bromo-2,2-bis (bromomethyl) propyl acetate, the starting material is selected pentaerythritol, the reaction temperature is reduced from 90 ° C to 50 ° C, the reaction time is shortened from about 35 hours to about 10 hours, shortening the reaction time, reducing the reaction temperature, greatly reducing the production cost; the use of bromine-containing materials in the reaction process, to achieve the recovery of bromine elements, greatly reducing the output of waste, At the same time, it also solves the problem that cyclopropyl dimethylol contains two hydroxyl groups, only one hydroxyl group needs to be protected; further, the present invention uses a cyanide solution instead of a cyanide solid, reducing the risk of direct contact between the operator and the cyanide-containing material. The raw materials used in the present invention are simple and readily available, the process flow is simple, suitable for industrial large-scale production.

SPIROPYRROLIDINES AS MDM2 INHIBITORS

Described are spiropyrrolidines (I) useful as inhibitors of MDM2/p53 interactions and provides useful agents for the treatment of diseases like cancer and retinal macular degeneration diseases. The invented compounds herein have the general Further described are pharmaceutical compositions that comprise one or more compounds of the invention, a pharmaceutically acceptable salt or pro-drug and/or a pharmaceutically acceptable carrier or excipient.

Process for preparation of [1-(mercaptomethyl)cyclopropyl]acetic acid and related derivatives

The present invention provides a novel process for preparing [1-(mercaptomethyl)cyclopropyl]acetic acid with high purity and related derivatives.