3384-46-1Relevant academic research and scientific papers
Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors
Kobayakawa, Takuya,Tsuji, Kohei,Konno, Kiju,Himeno, Ai,Masuda, Ami,Yang, Tingting,Takahashi, Kohei,Ishida, Yusuke,Ohashi, Nami,Kuwata, Takeo,Matsumoto, Kaho,Yoshimura, Kazuhisa,Sakawaki, Hiromi,Miura, Tomoyuki,Harada, Shigeyoshi,Matsushita, Shuzo,Tamamura, Hirokazu
supporting information, p. 1481 - 1496 (2021/02/27)
CD4 mimics are small molecules that inhibit the interaction of gp120 with CD4. We have developed several CD4 mimics. Herein, hybrid molecules consisting of CD4 mimics with a long alkyl chain or a PEG unit attached through a self-cleavable linker were synthesized. In anti-HIV activity, modification with a PEG unit appeared to be more suitable than modification with a long alkyl chain. Thus, hybrid molecules of CD4 mimics, with PEG units attached through an uncleavable linker, were developed and showed high anti-HIV activity and low cytotoxicity. In investigation of pharmacokinetics in a rhesus macaque, a hybrid compound had a more effective PK profile than that of the parent compound, and intramuscular injection was a more useful administration route to maintain the high blood concentration of the CD4 mimic than intravenous injection. The presented hybrid molecules of CD4 mimics with a PEG unit would be practically useful when combined with a neutralizing antibody.
OIL THICKENING AGENT
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Paragraph 0029, (2019/03/26)
PROBLEM TO BE SOLVED: To provide oil thickening agents which dissolve in oils readily and form a transparent oil gel. SOLUTION: The present invention provides an oil thickening agent which is a compound having an unsymmetrical diamide structure represented by formula (I) or (II). The invention also provides cosmetics, skin external preparations, and emulsion compositions containing the thickener. [R1 is a saturated or unsaturated straight chain alkyl group, alkenyl group, or alkynyl group of C9 to 30; A is an alkylene group of C1 to 10, an aralkylene group or arylene group having 8 to 10 carbon atoms; and R2 is a saturated/unsaturated branched alkyl group having 7 to 30 carbon atoms.] SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT
