33856-02-9

Upstream product

• 29310-88-1 3-bromoacetylcoumarin 
• 103-85-5 monophenylthiourea 
• 3949-36-8 3-acetylcoumarin 
• 453524-57-7 ethyl-2-(2-(phenylamino)thiazol-4-yl)acetate 
• 90-02-8 salicylaldehyde 
• 141099-74-3 3-(2-thiocyanatoacetyl)-2H-1-benzopyran-2-one 
• 62-53-3 aniline 

Downstream Products

• 33856-10-9 3-(2-anilino-5-bromo-thiazol-4-yl)-chromen-2-one 
• 108222-34-0 3-[2-(N-acetyl-anilino)-thiazol-4-yl]-coumarin 
• 936096-68-3 2-phenylamino-4-(coumarin-3-yl)-5-formylthiazole 

Relevant academic research and scientific papers

An expedient one-pot tandem method for the synthesis of 3-(2-(phenylamino)thiazol-4-yl)-2H-chromen-2-ones under green conditions

This paper describes a facile pathway for the one-pot three-component synthesis of 3-(2-(phenylamino)thiazol-4-yl)-2H-chromen-2-ones starting from ethyl-4-chloroacetoacetate by treating it with equimolar amounts of various phenylthioureas independently re

PEG-600 mediated one-pot reaction of 3-acetyl-2: H -chromen-2-one with heterylthiols and phenylthioureas using tetrabutylammonium tribromide as an efficient green reagent

A simple method for the one-pot reaction of 3-acetyl-2H-chromen-2-one with different heterylthiols and phenylthioureas under green conditions using tetrabutylammonium tribromide (TBATB) as an efficient reagent has been described. 3-Acetyl-2H-chromen-2-one

Green approach: An efficient synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles in aqueous medium under ultrasonic irradiation

An efficient and rapid procedure for the synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles has been described by the reaction of α-bromoketones with thiourea, phenylthiourea and selenourea at ambient temperature in aqueous medium under ultrasonic irradiation. Analytically pure products were formed within 10-60 s in excellent yields. The advantageous features of this non-conventional methodology over conventional methods are the operational simplicity, easy handling, yield-enhancing, time-reducing, mild reaction conditions and no by-product production.

Sodium fluoride as an efficient catalyst for the synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles at ambient temperature

Sodium fluoride was found to be a simple, mild and efficient catalyst for the synthesis of 2,4-disubstituted 1,3-thiazoles and selenazoles utilizing phenacyl bromides/3-(2-bromoacetyl)-2H-chromen-2-one and thiourea/ phenylthiourea/selenourea in aqueous methanol at ambient temperature. Analytically pure products are formed within 1-3 min in excellent yields.

One pot synthesis of 3-[2-(arylamino)thiazol-4-yl]coumarins in a three-component synthesis and a catalyst and solvent-free synthesis on grinding

An efficient synthesis of 3-[2-(arylamino)thiazol-4-yl]coumarins in excellent yields are described. Reaction of 3-(2-bromoacetyl)coumarin with potassium thiocyanate and arylamines, in alcohol resulted in the formation of title compounds in one pot. The sa

Intramolecular amidation: Synthesis of novel thiazole-fused diazepinones

A new class of thiazole-fused diazepinones has been synthesized by the application of intramolecular hydrazonolysis, wherein 2-arylamino-4-coumarinyl- 5-formyl thiazoles were treated with hydrazine hydrate in refluxing ethanol to yield the rearranged prod

A NOVEL SYNTHESIS OF THIAZOLYL, IMIDAZOTHIADIAZOLYL, AND THIADIAZINYL-2H-1-BENZOPYRAN-2-ONES

3-Acetylcoumarins I with arylthiourea in the presence of iodine gave substituted-3-(2-arylamino-4-thiazolyl)-2H-1-benzopyran-2-ones (IIa-IIc.) The structures of these products have been confirmed and they were converted into acetyl derivatives (IId-IIf.)