33859-67-5Relevant academic research and scientific papers
1,2,4-triazine N-oxide and N,N′-dioxide derivatives: Studies as potential hypoxic cytotoxins and DNA binder
Cerecetto,Gonzalez,Onetto,Risso,Saenz,Seoane,Bruno,Alarcon,Olea-Azar,Lopez de Cerain,Ezpeleta,Monge
, p. 328 - 337 (2007/10/03)
1,2,4-Triazine N-oxide and N,N′-dioxide derivatives were synthesized in order to obtain compounds as potential selective hypoxic cell cytotoxins. All the compounds were tested for their cytotoxicity in oxia and hypoxia and some of them for their capacity to DNA-interaction in oxia. They proved to be less active in hypoxic conditions than the parent compound, tirapazamine (3-aminobenzo[1,2-e]1,2,4-triazine N1,N4-dioxide). However, derivatives 6, 9, and 10 developed significant affinity for DNA in oxic conditions. The electrochemical properties revealed that the lack of hypoxic - cytoxicity was clearly related with their poor bioreductive characteristics.
