33860-28-5

Basic information

• Product Name: 4-METHYLPIPERAZINE-1-CARBOTHIOAMIDE
• Synonyms: 4-methylpiperazine-1-carbothioamide(SALTDATA: FREE);4-Methyl-1-piperazinyl-thiocarboxaMide;4-methyl-1-Piperazinecarbothioamide
• CAS NO: 33860-28-5
• Molecular Formula: C₆H₁₃N₃S
• Molecular Weight: 159.25
• Mol File: 33860-28-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 247.2°Cat760mmHg
• Flash Point: 103.3°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.026mmHg at 25°C
• PKA: 16.22±0.20(Predicted)
• CAS DataBase Reference: 4-METHYLPIPERAZINE-1-CARBOTHIOAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYLPIPERAZINE-1-CARBOTHIOAMIDE(33860-28-5)
• EPA Substance Registry System: 4-METHYLPIPERAZINE-1-CARBOTHIOAMIDE(33860-28-5)

Safety Data

• Hazardous Substances Data: 33860-28-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H13N3S/c1-8-2-4-9(5-3-8)6(7)10/h2-5H2,1H3,(H2,7,10)/p+1

Upstream product

• 18739-36-1 4-methyl-piperazine-1-carbothioyl chloride 
• 109-01-3 1-methyl-piperazine 
• 333-20-0 potassium thioacyanate 
• 1039455-83-8 imidazol-1-yl-(4-methyl-piperazin-1-yl)-methanethione 
• 88681-68-9 di(1H-imidazol-2-yl)methanethione 
• 6160-65-2 1,1'-Thiocarbonyldiimidazole 
• 50398-09-9 N-methylpiperazine dihydrochloride 

Downstream Products

• 294622-47-2 4-[2-(4-methyl-piperazin-1-yl)-thiazol-4-yl]-benzoic acid 
• 909707-15-9 C₁₄H₁₆BrN₃S 
• 219598-17-1 2(S)-<(2-benzoylphenyl)amino>-3-<4-<2-<5-methyl-2-(4-methylpiperazin-1-yl)thiazol-4-yl>ethoxy>phenyl>propionic acid methyl ester 
• 860344-60-1 3-[2-(4-methyl-piperazin-1-yl)-thiazol-4-yl]-benzoic acid 
• 1160623-75-5 N-(3-(5-(2-chloro-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide 
• 1307271-61-9 N-{2-fluoro-3-[5-(2-{[(2S)-2-hydroxypropyl]amino}-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide 
• 1307272-05-4 N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-1-propanesulfonamide 
• 1394938-83-0 N-{2,4-difluoro-3-[2-(4-methyl-piperazin-1-yl)-thiazol-4-yl]-phenyl}-2,5-difluoro-benzenesulfonamide 
• 1094358-13-0 Methyl 3-fluoro-4-[2-(4-methylpiperazin-1-yl)-thiazol-4-yl]benzoate 
• 1059549-57-3 4-[5-fluoro-2-(4-methyl-piperazin-1-yl)-thiazol-4-yl]-benzoic acid methyl ester 
• 294623-49-7 CRA-03783 

Relevant articles and documents

THIAZOLE AND OXAZOLE KINASE INHIBITORS

The present invention provides thiazole and oxazole compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.

CYSTEINE PROTEASE INHIBITORS

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CYSTEINE PROTEASE INHIBITORS

A compound of the formula (II) wherein one of R1 and R2 is halo and the other is H or halo; R3 is C1-C4 straight or branched chain, optionally fluorinated, alkyl; R4 is H; or R3 together with R4 and the adjoining backbone carbon defines: a spiro-C5-C7 cycloalkyl, optionally substituted with 1 to 3 substituents selected from halo, hydroxyl, C1-C4 alkyl or C1-C4 haloalkyl; or optionally bridged with a methylene group; or a C4-C6 saturated heterocycle having a hetero atom selected from O, NRa, S, S(=O)2 ; where Ra is H, C1-C4 alkyl or CH3C(=O); R5 is independently selected from H or methyl; E is -C(=O)-, -S(=O)m-, -NR5S(=O)m-, -NR5C(=O)-, -OC(=O)-, R6 is a stable, optionally substituted, monocyclic or bicyclic, carbocycle or hetorocycle; m is independently 0,1 or 2; are inhibitors of cathepsin K and useful in the treatment or prophylaxis of osteoporosis.