33866-44-3

Basic information

• Product Name: 3-(2-FURYL)ISOXAZOL-5-AMINE
• Synonyms: 5-Isoxazolamine,3-(2-furanyl)-(9CI);3-Fur-2-ylisoxazol-5-ylamine;5-Amino-3-(fur-2-yl)isoxazole
• CAS NO: 33866-44-3
• Molecular Formula: C₇H₆N₂O₂
• Molecular Weight: 150.13
• Product Categories: OXAZOLE;AMINEPRIMARY
• Mol File: 33866-44-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 358.5°Cat760mmHg
• Flash Point: 170.6°C
• Appearance: /
• Density: 1.296g/cm³
• Vapor Pressure: 2.54E-05mmHg at 25°C
• Refractive Index: 1.565
• PKA: -1.78±0.50(Predicted)
• CAS DataBase Reference: 3-(2-FURYL)ISOXAZOL-5-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-FURYL)ISOXAZOL-5-AMINE(33866-44-3)
• EPA Substance Registry System: 3-(2-FURYL)ISOXAZOL-5-AMINE(33866-44-3)

Safety Data

• Hazardous Substances Data: 33866-44-3(Hazardous Substances Data)

Usage

General Description

3-(2-furyl)isoxazol-5-amine is a chemical compound that belongs to the class of isoxazoles, which are five-membered heterocyclic compounds that contain an oxygen and a nitrogen atom in the ring. This specific compound contains a furan ring (a five-membered aromatic ring with four carbon atoms and one oxygen atom) attached to the isoxazole ring. It has potential applications in medicinal and pharmaceutical research due to its interesting structural features and potential biological activities. The compound has been studied for its potential as a drug candidate in the treatment of various diseases and conditions, and its synthesis and properties have been investigated in scientific research.

InChI:InChI=1/C7H6N2O2/c8-7-4-5(9-11-7)6-2-1-3-10-6/h1-4H,8H2

Upstream product

• 614-99-3 Ethyl 2-furoate 
• 75-05-8 acetonitrile 
• 31909-58-7 2-furoylacetonitrile 

Relevant articles and documents

An enantioselective aza-Friedel-Crafts reaction of 5-aminoisoxazoles with isatin-derived: N -Boc ketimines

By employing a chiral phosphoric acid as a catalyst, an enantioselective aza-Friedel-Crafts reaction of 5-aminoisoxazoles with isatin-derived N-Boc ketimines was realized. The reaction provided a wide variety of novel 3-isoxazole 3-amino-oxindoles with good yields (up to 99%) and moderate to good enantioselectivities (up to 99%). The absolute configuration of one product was assigned by X-ray crystal structural analysis and a plausible reaction mechanism was proposed. In addition, a scale-up reaction was performed successfully. Finally, one product was subjected to Suzuki-Miyaura coupling with phenylboronic acid to afford the product in a moderate yield without erosion of the enantioselectivity. This journal is

Hoveyda-Grubbs II Catalyst: A Useful Catalyst for One-Pot Visible-Light-Promoted Ring Contraction and Olefin Metathesis Reactions

A one-pot reaction to synthesize functionalized 2H-azirines through visible-light-mediated ring contraction and olefin metathesis of isoxazoles is described. Hoveyda-Grubbs II catalyst was found to function as a photocatalyst for these transformations, al