Welcome to LookChem.com Sign In|Join Free
  • or
α-N-Benzoyl-ε-N-carbobenzoxy-L-lysin-tert-butylester is a complex organic compound that serves as a protected form of the amino acid L-lysine. It is widely used in peptide synthesis, where the benzoyl and carbobenzoxy groups act as protecting groups for the amino and carboxyl groups, respectively, preventing unwanted side reactions. The tert-butylester group further protects the hydroxyl group of the lysine side chain. α-N-Benzoyl-ε-N-carbobenzoxy-L-lysin-tert-butylester is crucial in the synthesis of peptides and proteins, as it allows for the controlled addition of amino acids in a stepwise manner, ensuring the correct sequence and structure of the final product. The protecting groups are removed at specific stages of the synthesis process, ultimately yielding the desired peptide or protein.

33869-64-6

Post Buying Request

33869-64-6 Suppliers

Recommended suppliers

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

33869-64-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 33869-64-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,8,6 and 9 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 33869-64:
(7*3)+(6*3)+(5*8)+(4*6)+(3*9)+(2*6)+(1*4)=146
146 % 10 = 6
So 33869-64-6 is a valid CAS Registry Number.

33869-64-6Relevant academic research and scientific papers

Nonpeptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity

Schmitt, Martin L.,Hauser, Alexander-Thomas,Carlino, Luca,Pippel, Martin,Schulz-Fincke, Johannes,Metzger, Eric,Willmann, Dominica,Yiu, Teresa,Barton, Michelle,Schüle, Roland,Sippl, Wolfgang,Jung, Manfred

, p. 7334 - 7342 (2013/10/21)

Lysine demethylases play an important role in epigenetic regulation and thus in the development of diseases like cancer or neurodegenerative disorders. As the lysine specific demethylase 1 (LSD1/KDM1) has been strongly connected to androgen and estrogen dependent gene expression, it serves as a promising target for the therapy of hormone dependent cancer. Here, we report on the discovery of new small molecule inhibitors of LSD1 containing a propargylamine warhead, starting out from lysine containing substrate analogues. On the basis of these substrate mimicking inhibitors, we were able to increase potency by a combination of similarity-based virtual screening and subsequent synthetic optimization resulting in more druglike LSD1 inhibitors that led to histone hypermethylation in breast cancer cells.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1 Customer Service

What can I do for you?
Get Best Price

Get Best Price for 33869-64-6