56917-39-6

Basic information

• Product Name: 1-(2'-METHYL[1,1'-BIPHENYL]-4-YL)ETHANONE
• Synonyms: AKOS BAR-0223;1-(2'-METHYL-BIPHENYL-4-YL)-ETHANONE;1-(2'-METHYL[1,1'-BIPHENYL]-4-YL)ETHANONE
• CAS NO: 56917-39-6
• Molecular Formula: C₁₅H₁₄O
• Molecular Weight: 210.27
• Mol File: 56917-39-6.mol
• Article Data: 111

Chemical Properties

• Boiling Point: 324 °C at 760 mmHg
• Flash Point: 137.5 °C
• Appearance: /
• Density: 1.038g/cm³
• CAS DataBase Reference: 1-(2'-METHYL[1,1'-BIPHENYL]-4-YL)ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2'-METHYL[1,1'-BIPHENYL]-4-YL)ETHANONE(56917-39-6)
• EPA Substance Registry System: 1-(2'-METHYL[1,1'-BIPHENYL]-4-YL)ETHANONE(56917-39-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 56917-39-6(Hazardous Substances Data)

Usage

General Description

1-(2'-Methyl[1,1'-biphenyl]-4-yl)ethanone, also known as 4’-Methyl-1,1'-biphenyl-2-carbaldehyde, is an aromatic ketone compound with a molecular formula of C15H14O. It belongs to the family of biphenyl compounds and is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. It is used in the production of fragrance and flavoring agents, as well as in the manufacture of organic dyes and pigments. This chemical has potential applications in the food and beverage, cosmetic, and pharmaceutical industries due to its aromatic properties and reactivity in organic synthesis. It is important to handle this chemical with caution as it may pose health hazards if not properly managed.

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Relevant articles and documents

Highly effective activation of aryl chlorides for Suzuki coupling in aqueous media using a ferrocene-based Pd(II)-diimine catalyst

The Suzuki coupling of aryl chlorides with boronic acids using a ferrocene-containing Pd(II)-diimine complex as catalyst, in aqueous media, under microwave heating is reported. A small amount of the catalyst (0.1%) was found to be highly effective for coupling unactivated aryl chlorides with boronic acids to form sterically hindered ortho-substituted biaryls. The same catalyst also enabled the coupling of aryl bromides and iodides with various boronic acids in very high yields. The catalyst is air stable and the catalytic reaction can be completed in 15 min.

Highly Active Fe3O4@SBA-15@NHC-Pd Catalyst for Suzuki–Miyaura Cross-Coupling Reaction

A novel Pd-NHC functionalized magnetic Fe3O4@SBA-15@NHC-Pd was synthesized and used as an efficient heterogeneous catalyst in the Suzuki–Miyaura C–C bond formation reactions. The Fe3O4@SBA-15@NHC-Pd characterized by X-Ray Diffraction (XRD), X-ray Photoelectron Spectroscopy (XPS), Fourier Transform Infrared (FTIR) spectroscopy, Scanning Electron Microscopy (SEM), Transmission Electron Microscopy?(TEM), Energy Dispersive X-ray analysis (EDX), Thermogravimetric Analysis (TGA), Differential Thermal Analysis (DTA). The Inductively Coupled Plasma-Optical emission spectroscopy (ICP-OES)?analysis was used to determine the exact amount of Pd (0.33?wt%) in Fe3O4@SBA-15@NHC-Pd. The TEM images of the catalyst showed the existence of palladium nanoparticles immobilized in the catalyst's structure, while no reducing agent was used. The NHC moieties in the catalyst structure could be stabilize Pd(0) nanoparticles prevents agglomeration. The magnetic catalyst was effectively used in the Suzuki–Miyaura cross-coupling reaction of substituted phenylboronic acid derivatives with (hetero)aryl bromides in the presence of a K2CO3 at room temperature in aqueous media and magnetic catalyst could be simply extracted from the reaction mixture by an external magnet. Different aryl bromides were converted to coupled-products in excellent yields with spectacular TOFs values (up to 1,960,339?h?1); in the presence of 1?mg of Fe3O4@SBA-15@NHC-Pd catalyst (contains 3.1 × 10–6?mol% Pd) at room temperature in aqueous media. After reusability experiments, it is found that this catalyst was effectively used up to ten times in the reaction with almost consistent catalytic efficiency. A decrease in the activity of the 10th reused catalyst was found as 9%. Graphic Abstract: [Figure not available: see fulltext.]

Method for synthesizing biphenyl compound by taking suaeda salsa extract liquor as solvent

The invention discloses a method for synthesizing a biphenyl compound by using suaeda salsa extract as a solvent in the technical field of organic chemical synthesis, which comprises the following steps: roasting suaeda salsa in a muffle furnace to obtain ash, dissolving the ash in distilled water, refluxing, cooling the solution, and filtering to obtain a faint yellow solution which is the suaedasalsa extract liquor; sequentially adding 1mmol of aryl halide, 1.1mmol of arylboronic acid, 0.001mmol to 0.01mmol of a catalyst and 4ml of the suaeda salsa extract liquor into a round-bottom flask,stirring at 100 DEG C to react for 2 hours, cooling the reactant to room temperature, filtering, mixing the obtained filter residue with a palladium catalyst to obtain a mixture; and dissolving the mixture in ethyl acetate, filtering to remove the palladium catalyst, and drying the filtrate by distillation to obtain the biphenyl compound. According to the scheme, a phosphine ligand, alkali and anadditive do not need to be added, a Suzuki reaction system with biomass extract as a reaction medium is adopted, and a green, simple, convenient and efficient method is provided for synthesizing biphenyl compounds.