338731-17-2Relevant academic research and scientific papers
The synthesis of amino acid bridged dicatechol derivatives
Albrecht,Napp,Schneider
, p. 468 - 472 (2007/10/03)
Amino acid bridged dicatechol ligands 1a-e are synthesized by a stepwise coupling procedure. First 2,3-dimethoxybenzoic acid (2) is coupled with the amino acid (3a-e) followed by a second coupling step of the obtained derivatives 4a-e with 2,3-dimethoxybenzyl amine (5). As coupling reagents for the amide bonds either DDC/NHS or EDC/HOBt are used. In the final step of the reaction sequence the methyl ethers of the ligand precursors 6a-e are cleaved with BBr3 to obtain the dicatechol ligands 1a-e, which are potential building blocks for metallo-supramolecular chemistry.
