338741-26-7Relevant academic research and scientific papers
Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor α selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4- yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453)
Li, Jun,Kennedy, Lawrence J.,Shi, Yan,Tao, Shiwei,Ye, Xiang-Yang,Chen, Stephanie Y.,Wang, Ying,Hernández, Andrés S.,Wang, Wei,Devasthale, Pratik V.,Chen, Sean,Lai, Zhi,Zhang, Hao,Wu, Shung,Smirk, Rebecca A.,Bolton, Scott A.,Ryono, Denis E.,Zhang, Huiping,Lim, Ngiap-Kie,Chen, Bang-Chi,Locke, Kenneth T.,O'Malley, Kevin M.,Zhang, Litao,Srivastava, Rai Ajit,Miao, Bowman,Meyers, Daniel S.,Monshizadegan, Hossain,Search, Debra,Grimm, Denise,Zhang, Rongan,Harrity, Thomas,Kunselman, Lori K.,Cap, Michael,Kadiyala, Pathanjali,Hosagrahara, Vinayak,Zhang, Lisa,Xu, Carrie,Li, Yi-Xin,Muckelbauer, Jodi K.,Chang, Chiehying,An, Yongmi,Krystek, Stanley R.,Blanar, Michael A.,Zahler, Robert,Mukherjee, Ranjan,Cheng, Peter T. W.,Tino, Joseph A.
scheme or table, p. 2854 - 2864 (2010/08/22)
An 1,3-oxybenzylglycine based compound 2 (BMS-687453) was discovered to be a potent and selective peroxisome proliferator activated receptor (PPAR) α agonist, with an EC50 of 10 nM for human PPARα and -410-fold selectivity vs human PPAR- in PPA
