338752-84-4Relevant academic research and scientific papers
Microwave-enhanced efficient synthesis of some polyfunctional pyridazines
Kumar Jangid,Yadav,Yadav
, p. 1165 - 1173 (2013/10/21)
Microwave-enhanced highly efficient protocol for the synthesis of polyfunctional pyridazines beginning from 3,6-dichloropyridazine in environmentally benign ionic liquids have been developed. The products obtained were 3-amino-6-chloropyridazine, 3,6-diaminopyridazine, and 3-chloro-6- methoxypyridazine. These derivatives were then be converted to a variety of polyfunctional pyridazine derivatives. The ionic liquids used were 1-n-butyl-3-methylimidazolium hydroxide/tetrafluoroborate/hexafluorophosphate and 1,3-di-n-butylimidazolium hydroxide. This powerful strategy is less time-consuming green methodology. The ionic liquid employed may be recovered and recycled.
The discovery of VX-745: A novel and selective p38α kinase inhibitor
Duffy, John P.,Harrington, Edmund M.,Salituro, Francesco G.,Cochran, John E.,Green, Jeremy,Gao, Huai,Bemis, Guy W.,Evindar, Ghotas,Galullo, Vincent P.,Ford, Pamella J.,Germann, Ursula A.,Wilson, Keith P.,Bellon, Steven F.,Chen, Guanging,Taslimi, Paul,Jones, Peter,Huang, Cassey,Pazhanisamy,Wang, Yow-Ming,Murcko, Mark A.,Su, Michael S.S.
scheme or table, p. 758 - 763 (2011/12/03)
The synthesis of novel, selective, orally active 2,5-disubstituted 6H-pyrimido[1,6-b]pyridazin-6-one p38α inhibitors is described. Application of structural information from enzyme-ligand complexes guided the selection of screening compounds, leading to t
Synthesis, fungicidal and antibacterial activity of new pyridazine derivatives
Foks, Henryk,Wisterowicz, Krystyna,Miszke, Agnieszka,Brozewicz, Kamil,Wisniewska, Katarzyna,Dabrowska-Szponar, Maria
experimental part, p. 961 - 975 (2009/09/30)
Compounds 1-3 were obtained in the reaction of 3,6-dichloro-pyridazines with phenylacetonitriles in the biphasic system - DMSO/50% NaOH. The chlorine atom was replaced with cycloalkylamino (4-13) and hydrazinyl (23, 24) moiety. These last compounds were condensed with aldehydes (25-34). Pyridazynylphenylacetonitriles were converted into amides 14-18 and thioamides 19-22. In compounds 2, 3 the chlorine atom was replaced with thiophenyl (37, 38) and in compound 1 with thioethyl and thiophenyl (35, 36) functional groups. In the reactions of compounds 1, 2 with ammonium polysulfide thioamides with thiol group (39, 40) and chlorine atom (41, 42) were obtained. Compounds 1-17, 19-43 were screened for antibacterial and fungicidal activities.
