33876-67-4

Basic information

• Product Name: Phenyl <(4-methylphenyl)hydrazono>methyl ketone
• Synonyms: Phenyl <(4-methylphenyl)hydrazono>methyl ketone
• CAS NO: 33876-67-4
• Molecular Weight: 238.289
• Mol File: 33876-67-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Phenyl <(4-methylphenyl)hydrazono>methyl ketone(CAS DataBase Reference)
• NIST Chemistry Reference: Phenyl <(4-methylphenyl)hydrazono>methyl ketone(33876-67-4)
• EPA Substance Registry System: Phenyl <(4-methylphenyl)hydrazono>methyl ketone(33876-67-4)

Safety Data

• Hazardous Substances Data: 33876-67-4(Hazardous Substances Data)

Upstream product

• 614-20-0 3-oxo-3-phenylpropionic acid 
• 2028-84-4 p-methylbenzenediazonium chloride 
• 146767-34-2 4-Methylphenylazo tert-butyl sulfide 
• 98-86-2 acetophenone 
• 34438-71-6 acetophenone enolate 

Downstream Products

• 1265801-93-1 3-hydroxy-1-phenyl-2-(2-p-tolylhydrazono)propan-1-one 
• 1265802-08-1 3-amino-6-benzoyl-5-phenyl-2-p-tolyl-2,5-dihydropyridazine-4-carbonitrile 
• 1265802-14-9 3-amino-6-benzoyl-5-phenyl-2-p-tolyl-2,5-dihydropyridazine-4-carboxylic acid ethyl ester 
• 1414846-55-1 [6-(methylsulfonylmethyl)-1,4-di-p-tolyl-1,6-dihydropyridazin-3-yl](phenyl)methanone 
• 1414846-51-7 3-benzoyl-6-(methylsulfonylmethyl)-5-nitro-1,4-di-p-tolyl-1,4,5,6-tetrahydropyridazine 
• 1414846-45-9 (Z)-(5-(2-(methylthio)vinyl)-1,4-di-p-tolyl-1H-pyrazol-3-yl)(phenyl)methanone 
• 1414846-46-0 (E)-(5-(2-(methylthio)vinyl)-1,4-di-p-tolyl-1H-pyrazol-3-yl)(phenyl)methanone 
• 1414846-38-0 (E)-3-benzoyl-(4-methylstyryl)-5-(methylthio)-1-p-tolyl-1H-pyrazole 

Relevant articles and documents

Improved synthesis of 2-arylhydrazono-3-hydroxy-1-propanones and their utility in efficient synthesis of pyridazine derivatives

Reaction of 2-arylhydrazono-1-phenylethanones 2a-c with formaldehyde either in presence of montmorillonite K10 or by simply stirring in methanol and TEA leads to selective synthesis of 2-arylhydrazono-3-hydroxy-1-phenylpropan-1-one derivatives 3a-c in high yield. Heating 1a with N-phenylmaleimide in DPE/DABCO using microwave irradiation for 5 minutes at 200 °C results in a 73% yield of pyrrolo[3, 4-c]pyridazine 8. Compounds 2a-c react with benzylidenemalononitriles 9a or ethyl 2-cyanocinnamate 9b in refluxing ethanol and piperidine or β-chitosan to yield new pyridazine derivatives 10a-f which are converted into pyridazinones 11a-c upon reflux in acetic/hydrochloric acids mixture. ARKAT-USA, Inc.

α-arylation vs. α-arylhydrazonylation of alkyl aryl ketones with arylazo tert-butyl sulfides

Potassium enolates of alkyl aryl ketones react selectively in DMSO with phenylazo 1a and 4-methylphenylazo tert-butyl sulfide 1b undergoing respectively effective α-phenylation via S(RN)1 and α-(4-methylphenyl)hydrazonylation via elimination-addition.