338777-37-0

Basic information

• Product Name: N-(3-CYANO-2-THIENYL)-3-(TRIFLUOROMETHYL)BENZENECARBOXAMIDE
• Synonyms: N-(3-CYANO-2-THIENYL)-3-(TRIFLUOROMETHYL)BENZENECARBOXAMIDE;N-(3-cyanothiophen-2-yl)-3-(trifluoromethyl)benzamide
• CAS NO: 338777-37-0
• Molecular Formula: C₁₃H₇F₃N₂OS
• Molecular Weight: 296.27
• Mol File: 338777-37-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(3-CYANO-2-THIENYL)-3-(TRIFLUOROMETHYL)BENZENECARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-CYANO-2-THIENYL)-3-(TRIFLUOROMETHYL)BENZENECARBOXAMIDE(338777-37-0)
• EPA Substance Registry System: N-(3-CYANO-2-THIENYL)-3-(TRIFLUOROMETHYL)BENZENECARBOXAMIDE(338777-37-0)

Safety Data

• Hazardous Substances Data: 338777-37-0(Hazardous Substances Data)

Upstream product

• 4651-82-5 2-amino-3-cyanothiophene 
• 2251-65-2 3-(Trifluoromethyl)benzoyl chloride 

Relevant articles and documents

Biological activity of modified and exchanged 2-amino-5-nitrothiazole amide analogues of nitazoxanide

Head group analogues of the antibacterial and antiparasitic drug nitazoxanide (NTZ) are presented. A library of 39 analogues was synthesized and assayed for their ability to suppress growth of Helicobacter pylori, Campylobacter jejuni, Clostridium difficile and inhibit NTZ target pyruvate:ferredoxin oxidoreductase (PFOR). Two head groups assayed recapitulated NTZ activity and possessed improved activity over their 2-amino-5-nitrothiazole counterparts, demonstrating that head group modification is a viable route for the synthesis of NTZ-related antibacterial analogues.