33887-02-4

Basic information

• Product Name: Clonitrazolam
• Synonyms: Clonitrazolam;6-(2-Chlorophenyl)-1-methyl-8-nitro-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine;8-Nitro-6-(2-chlorophenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine;Clonazolam;8-Nitro-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine;6-(2-chloro-phenyl)-1-methyl-8-nitro-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine;Clonazolam (CRM)
• CAS NO: 33887-02-4
• Molecular Formula: C₁₇H₁₂ClN₅O₂
• Molecular Weight: 353.76248
• EINECS: -0
• Product Categories: pharmaceutical;research chemical;pharmaceutical intermediates;medical intermediate
• Mol File: 33887-02-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 576.0±60.0 °C(Predicted)
• Appearance: /
• Density: 1.53±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C
• PKA: 1.88±0.40(Predicted)
• CAS DataBase Reference: Clonitrazolam(CAS DataBase Reference)
• NIST Chemistry Reference: Clonitrazolam(33887-02-4)
• EPA Substance Registry System: Clonitrazolam(33887-02-4)

Safety Data

• RIDADR: UN 1648 3 / PGII
• Hazardous Substances Data: 33887-02-4(Hazardous Substances Data)

Usage

Description

Clonitrazolam is a benzodiazepine that was developed as a central nervous system depressant in the 1970s. It is known for its potent ability to antagonize convulsions induced by thiosemicarbazide and pentobarbital. In vitro phase I metabolites of Clonitrazolam, derived from human liver microsomes, have been described. It is categorized as a sedative and has been abused recreationally. This product is intended for forensic and research applications.
Used in Forensic Applications:
Clonitrazolam is used as a certified reference material for forensic purposes, helping in the identification and analysis of this substance in cases of drug abuse or criminal investigations.
Used in Research Applications:
Clonitrazolam is used as a research chemical to study its effects on the central nervous system, its potential therapeutic uses, and its metabolism in the human body. This helps in understanding the mechanisms of action and potential risks associated with its use.

Upstream product

• 136918-14-4 phthalimide 
• 54196-63-3 N-<<4-(2-Benzoyl-4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl>-methyl>phthalimide 
• 1972-28-7 diethylazodicarboxylate 

Relevant articles and documents

2-[3-(Phthalimidomethyl)-5-methyl-4H-1,2,4-triazol-4-yl]benzophenones

A process to make 6-phenyl-4H-s-triazolo[4,3-a][1,4]-benzodiazepines by converting 2-[3-(hydroxymethyl)-4H-1,2,4-triazol-4-yl]benzophenones to 2-[3-[(phthalimido or methanesulfonyl)methyl]-4H-1,2,4-triazol-4-yl]benzophenones and converting these compounds to the highly active 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines useful as tranquilizers and sedatives.