33893-85-5

Basic information

• Product Name: 4-(Hydroxymethyl)cyclohexanol (cis- and trans- mixture)
• Synonyms: 4-(Hydroxymethyl)cyclohexanol (cis- and trans- mixture);4-(Hydroxymethyl)cyclohexanol;4-(hydroxymethyl0cyclohexanol
• CAS NO: 33893-85-5
• Molecular Formula: C₇H₁₄O₂
• Molecular Weight: 260.371
• Mol File: 33893-85-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 28 °C
• Boiling Point: 122 °C / 1mmHg
• Flash Point: 127.191°C
• Appearance: /
• Density: 1.067g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.4910 to 1.4990
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 15.05±0.10(Predicted)
• CAS DataBase Reference: 4-(Hydroxymethyl)cyclohexanol (cis- and trans- mixture)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Hydroxymethyl)cyclohexanol (cis- and trans- mixture)(33893-85-5)
• EPA Substance Registry System: 4-(Hydroxymethyl)cyclohexanol (cis- and trans- mixture)(33893-85-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 33893-85-5(Hazardous Substances Data)

Usage

General Description

4-(Hydroxymethyl)cyclohexanol is a mixture of cis- and trans- isomers and is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and various other organic compounds. This chemical is a white, waxy solid with a slight odor and is soluble in water, alcohols, and ethers. It is a versatile intermediate that can undergo various chemical reactions, including esterification, oxidation, and reduction, to produce a range of different compounds with varied functionalities and properties. Its unique structure and reactivity make it a valuable component in the production of diverse and useful chemical products.

InChI:InChI=1/C7H14O2/c8-5-6-1-3-7(9)4-2-6/h6-9H,1-5H2

Upstream product

• 100-09-4 4-methoxybenzoic acid 
• 6297-22-9 4-carbomethoxycyclohexanone 
• 3618-04-0 4-hydroxycyclohexyl carboxylic acid ethyl ester 
• 120-57-0 piperonal 
• 64-17-5 ethanol 

Downstream Products

• 279-91-4 6-Thiabicyclo<3.2.1>octan 
• 38580-68-6 4-hydroxymethyl-cyclohexanone 
• 1653-30-1 undecan-2-ol 

Relevant articles and documents

MOF-derived hcp-Co nanoparticles encapsulated in ultrathin graphene for carboxylic acids hydrogenation to alcohols

Highly efficient conversion of carboxylic acids to valuable alcohols is a great challenge for easily corroded non-noble metal catalysts. Here, a series of few-layer graphene encapsulated metastable hexagonal closed-packed (hcp) Co nanoparticles were fabricated by reductive pyrolysis of metal-organic framework precursor. The sample pyrolyzed at 400 °C (hcp-Co@G400) presented outstanding performance and stability for converting a variety of functional carboxylic acids and its turnover frequency was one magnitude higher than that of conventional facc-centered cubic (fcc) Co catalysts. In situ DRIFTS spectroscopy of model reaction acetic acid hydrogenation and DFT calculation results confirm that carboxylic acid initially undergoes dehydroxylation to RCH2CO* followed by consecutive hydrogenation to RCH2CH2OH through RCH2COH*. Acetic acid prefers to vertically adsorb at hcp-Co (0 0 2) facet with a much lower adsorption energy than parallel adsorption at fcc-Co (1 1 1) surface, which plays a key role in decreasing the activation barrier of the rate-determining step of acetic acid dehydroxylation.

TRICYCLIC MODULATORS OF TNF SIGNALING

The invention provides tricyclic heterocyclic compounds, pharmaceutically acceptable salts, prodrugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the invention may be useful for treating immunological and oncological conditions.

Synthesis of epibatidine analogues having a 2-substituted 2-azabicyclo[2.2.2]octane skeleton

The synthesis of 1-cyano-2-aza-[2.2.2]bicyclooctanes has been studied using the dynamic cyanide addition to cyclohexanone derivatives. These compounds were further elaborated into a new class of epibatidine derivatives from which a number of examples were