338956-95-9

Upstream product

• 158817-21-1 (E)-5-(4-methoxybenzyloxy)pent-2-en-1-ol 
• 288-32-4 1H-imidazole 
• 146986-42-7 ((2S,3S)-3-(2-(4-methoxybenzyloxy)ethyl) oxiran-2-yl)methanol 
• 242808-65-7 ((2R,3R)-3-(2-(4-methoxybenzyloxy)ethyl)oxiran-2-yl)methanol 

Downstream Products

• 338956-97-1 (3R)-5-[(4-methoxybenzyl)oxy]pent-1-en-3-ol 
• 952092-37-4 (R)-3-methoxy-5-(4-methoxybenzyloxy)pent-1-ene 
• 952092-38-5 (1S,4S,5S,6S)-6-benzyloxy-4-[(1R,2R)-1-hydroxy-2-methoxy-4-(4-methoxybenzyloxy)butyl]-7,7-dimethyl-2-oxabicyclo[3.2.0]heptan-3-one 
• 952092-39-6 (2R,3R,4R)-2-[(1R,2S,4S)-2-benzyloxy-4-hydroxy-3,3-dimethylcyclobutyl]-4-methoxy-6-(4-methoxybenzyloxy)hexane-1,3-diol 
• 233609-28-4 (R)-2-methoxy-4-(4-methoxybenzyloxy)butyraldehyde 
• 146916-73-6 (S)-5-((4-methoxybenzyl)oxy)pent-1-en-3-ol 
• 338956-92-6 (5Z,7E,1R,3S,20S)-1,3-bis(tert-butyldimethylsilyloxy)-20-(3-methyl-3-trimethylsilyloxybutyloxy)-9,10-secopregna-5,7,10⁽¹⁹⁾-triene 
• 338956-85-7 (Z,3R,5S)-2-[3,5-bis(tert-butyldimethylsilyl)oxy-2-methylenecyclohexylideneethyl]diphenylphosphine oxide 
• 338956-81-3 (Z,3R,5S)-[3,5-bis(tert-butyldimethylsilyl)oxy-2-methylenecyclohexylidene]ethanol 
• 338956-83-5 (Z,3R,5S)-2-[3,5-bis(tert-butyldimethylsilyl)oxy-2-methylenecyclohexylidene]-1-chloroethane 
• 338956-99-3 (R)-tert-butyl(5-(4-methoxybenzyloxy)pent-1-en-3-yloxy)dimethylsilane 

Relevant academic research and scientific papers

Pestalotiopsin A. Side chain installation and exhaustive probing of olefin metathesis as a possible tool for elaborating the cyclononene ring

(Chemical Equation Presented) A program directed toward an asymmetric synthesis of pestalotiopsin A is described. The routing begins with the dextrorotatory cyclobutanol 37, which is combined with the enantiomerically defined building blocks ent-15 and 16

Synthesis and evaluation of A-ring diastereomers of 1α,25-dihydroxy-22-oxavitamin D3 (OCT)

A-ring diastereomers of 1α,25-dihydroxy-22-oxavitamin D3 (OCT) (2), 3-epi-1α,25-dihydroxy-22-oxavitamin D3 (3-epiOCT) (3) and 1,3-diepi-1α,25-dihydroxy-22-oxavitamin D3 (1,3-diepiOCT) (4) were synthesized by the convergent method. In vitro binding affinity for rat vitamin D binding protein and calf-thymus vitamin D receptor, differentiation-inducing activity on HL-60 cells, and transcriptional activity of 3-epiOCT (3) and 1,3-diepiOCT (4) were evaluated in comparison with OCT (2), 1-epi-1α,25-dihydroxy-22-oxavitamin D3 (1-epiOCT) (5) and 1α,25-dihydroxyvitamin D3 (1).

VITAMIN D DERIVATIVES AND PROCESS FOR PRODUCING THE SAME

The object of the present invention is to provide a novel 22-oxavitamin D derivative having a hydroxy group at both 1α- and 3α-positions. According to the present invention, there is provided 22-oxavitamin D derivatives having the following general formul