338959-30-1Relevant academic research and scientific papers
8-Piperazinyl-2,3-dihydropyrrolo[3,2-g]isoquinolines: Potent, selective, orally bioavailable 5-HT1 receptor ligands
Heightman, Tom D.,Gaster, Laramie M.,Pardoe, Sarah L.,Pilleux, Jean-Pierre,Hadley, Michael S.,Middlemiss, Derek N.,Price, Gary W.,Roberts, Claire,Scott, Claire M.,Watson, Jeannette M.,Gordon, Laurie J.,Holland, Vicky A.,Powles, Jenifer,Riley, Graham J.,Stean, Tania O.,Trail, Brenda K.,Upton, Neil,Austin, Nigel E.,Ayrton, Andrew D.,Coleman, Tanya,Cutler, Leanne
, p. 4370 - 4374 (2007/10/03)
The novel 8-piperazinyl-2,3-dihydropyrroloisoquinoline template was synthesized in nine steps. The template was N-substituted to give a series of compounds showing binding to human cloned 5-HT1A, 5-HT1B and 5-HT1D receptor
ISOQUINOLINE AND QUINAZOLINE DEIVATIVES HAVING A COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ACTIVITY
-
Page/Page column 8, (2010/02/10)
The invention relates to novel isoquinoline and quinazoline derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders.
