338959-28-7Relevant academic research and scientific papers
Pd-catalyzed direct and selective C-H functionalization: C3-acetoxylation of indoles
Liu, Qiang,Li, Gang,Yi, Hong,Wu, Pan,Liu, Jie,Lei, Aiwen
supporting information; experimental part, p. 2353 - 2357 (2011/04/24)
Direct functionalization of C-H bonds has been a hot topic in organic chemistry during recent years. Arenes-one of the most abundant chemical motifs-usually have multiple C-H bonds. Although, some examples of direct functionalizations of arenes have been
Palladium-catalyzed regioselective aerobic oxidative C-H/N-H carbonylation of heteroarenes under base-free conditions
Zhang, Hua,Liu, Dong,Chen, Caiyou,Liu, Chao,Lei, Aiwen
supporting information; experimental part, p. 9581 - 9585 (2011/10/02)
Clearing the air! By using a balloon pressure of CO, the direct oxidative carbonylation of various heteroarenes with different alcohols was achieved in good to high yields with air as the oxidant in the presence of PdCl 2(PPh3)2 (see scheme). Notably, this transformation was carried out under base-free conditions. The reaction showed remarkably high regioselectivity and presents an environmentally benign protocol for the synthesis of carboxylic acid derivatives.
8-Piperazinyl-2,3-dihydropyrrolo[3,2-g]isoquinolines: Potent, selective, orally bioavailable 5-HT1 receptor ligands
Heightman, Tom D.,Gaster, Laramie M.,Pardoe, Sarah L.,Pilleux, Jean-Pierre,Hadley, Michael S.,Middlemiss, Derek N.,Price, Gary W.,Roberts, Claire,Scott, Claire M.,Watson, Jeannette M.,Gordon, Laurie J.,Holland, Vicky A.,Powles, Jenifer,Riley, Graham J.,Stean, Tania O.,Trail, Brenda K.,Upton, Neil,Austin, Nigel E.,Ayrton, Andrew D.,Coleman, Tanya,Cutler, Leanne
, p. 4370 - 4374 (2007/10/03)
The novel 8-piperazinyl-2,3-dihydropyrroloisoquinoline template was synthesized in nine steps. The template was N-substituted to give a series of compounds showing binding to human cloned 5-HT1A, 5-HT1B and 5-HT1D receptor
ISOQUINOLINE AND QUINAZOLINE DEIVATIVES HAVING A COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ACTIVITY
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Page/Page column 8, (2010/02/10)
The invention relates to novel isoquinoline and quinazoline derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders.
