338964-93-5

Upstream product

• 94360-06-2 2-[3-(4-Bromo-phenyl)-3-oxo-1-phenyl-propyl]-malononitrile 
• 72758-69-1 (E)-1-(4-bromophenyl)-3-phenylprop-2-en-1-one 
• 101-41-7 benzeneacetic acid methyl ester 
• 99-90-1 para-bromoacetophenone 
• 22979-35-7 Methyl phenyldiazoacetate 
• 55779-43-6 4-[1-(4-Bromophenyl)ethenyl]morpholin 
• 133131-51-8 4-(4-bromophenyl)-4-oxo-2-phenylbutanenitrile 
• 71553-31-6 4-(4-bromo-phenyl)-4-oxo-2-phenyl-butyric acid 

Relevant academic research and scientific papers

One-Pot Quinine-Catalyzed Synthesis of α-Chiral γ-Keto Esters: Enantioenriched Precursors of cis-α,γ-Substituted-γ-Butyrolactones

A highly enantioselective one-pot synthesis of important building blocks, α-chiral γ-keto esters, has been developed by combining a quinine-catalyzed Michael addition of malononitrile to trans-enones followed by magnesium monoperoxyphthalate (MMPP) oxidat

New reaction of enamines with aryldiazoacetates catalyzed by transition metal complexes

The reaction of aryldiazoacetates with enamines catalyzed by copper and rhodium complexes provided γ-keto esters in good yields. A full investigation of the effects of solvents, catalysts, enamines and aryldiazoacetates on the reaction was carried out. Careful analysis of the crude reaction mixture revealed a substituted enamine as the primary product, which was hydrolyzed over silica gel to give a γ-keto ester as the final product. A reaction mechanism involving nucleophilic addition of an enamine to a metal carbene and subsequent hydrogen transfer was proposed. Chiral dirhodium and copper catalysts were examined and found to provide γ-keto esters with no enantioselectivity. The result could be rationalized based on the proposed reaction mechanism. Attempts to trap the enamine intermediate with several electrophilic reagents were not successful.