338975-16-9Relevant academic research and scientific papers
Potent synthetic inhibitors of tyrosyl tRNA synthetase derived from C-pyranosyl analogues of SB-219383
Jarvest, Richard L,Berge, John M,Brown, Pamela,Hamprecht, Dieter W,McNair, David J,Mensah, Lucy,O'Hanlon, Peter J,Pope, Andrew J
, p. 715 - 718 (2001)
Novel pyranosyl analogues of SB-219383 have been synthesised to elucidate the structure-activity relationships around the pyran ring. Analogues with highly potent stereoselective and bacterioselective inhibition of bacterial tyrosyl tRNA synthetase have been identified. A major reduction in the overall polarity of the molecule can be tolerated without loss of the nanomolar level of inhibition.
