Bioorganic and Medicinal Chemistry Letters p. 715 - 718 (2001)
Update date:2022-08-04
Topics:
Jarvest, Richard L
Berge, John M
Brown, Pamela
Hamprecht, Dieter W
McNair, David J
Mensah, Lucy
O'Hanlon, Peter J
Pope, Andrew J
Novel pyranosyl analogues of SB-219383 have been synthesised to elucidate the structure-activity relationships around the pyran ring. Analogues with highly potent stereoselective and bacterioselective inhibition of bacterial tyrosyl tRNA synthetase have been identified. A major reduction in the overall polarity of the molecule can be tolerated without loss of the nanomolar level of inhibition.
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