33898-72-5

Usage

Uses

Used in Pharmaceutical Synthesis:
1-Benzyl-1H-tetrazole-5-thiol is utilized as a precursor in the synthesis of pharmaceuticals, contributing to the development of new drugs. Its unique structure allows it to be a key component in the creation of novel therapeutic agents.
Used in Material Science:
In the field of material science, 1-benzyl-1H-tetrazole-5-thiol is employed in the development of new materials. Its chemical properties make it a valuable building block for the creation of innovative materials with potential applications in various industries.
Used in Chemical Reactions:
1-Benzyl-1H-tetrazole-5-thiol is also used in various chemical reactions, where its unique structure and properties can facilitate specific transformations or provide new pathways for chemical synthesis.
Used in Research:
Due to its potential biological and industrial applications, 1-benzyl-1H-tetrazole-5-thiol is of interest in research. Scientists are exploring its capabilities and properties to uncover new uses and understand its interactions within different systems.

InChI:InChI=1/C8H8N4S/c13-8-9-10-11-12(8)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,11,13)

Upstream product

• 13078-31-4 N-benzyl-1,2,3,4-thiatriazol-5-amine 
• 6392-77-4 methyl N-(benzyl)carbamodithioate 
• 622-78-6 Benzyl isothiocyanate 
• 13431-41-9 4-benzylthiosemicarbazide 

Downstream Products

• 53078-74-3 1-benzyl-5-methylsulfanyl-1H-tetrazole 
• 53798-95-1 1-benzyl-4,5-dihydro-1H-1,2,3,4-tetrazol-5-one 
• 1618101-10-2 1-benzyl-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazole 
• 1296865-61-6 1-benzyl-5-[(3-bromopropyl)thio]-1H-tetrazole 
• 1043192-79-5 5,5'-[1,3-propanediylbis(thio)]bis(1-benzyl-1H-tetrazole) 
• 1296865-68-3 5-[3-(1-benzyl-1H-tetrazol-5-ylthio)propylthio]-4-ethyl-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1296865-67-2 1-benzyl-5-[3-(1-cyclopropyl-1H-tetrazol-5-ylthio)propylthio]-1H-tetrazole 
• 1296865-66-1 1-benzyl-5-[3-(1-ethyl-1H-tetrazol-5-ylthio)propylthio]-1H-tetrazole 
• 1296865-65-0 2-[3-(1-benzyl-1H-tetrazol-5-ylthio)propyl]-6-bromo-1,2,3,4-tetrahydroisoquinoline 
• 1296865-64-9 2-[3-(1-benzyl-1H-tetrazol-5-ylthio)propyl]-1,2,3,4-tetrahydroisoquinoline 
• 1296865-63-8 3-(1-benzyl-1H-tetrazol-5-ylthio)-N-methyl-N-phenethylpropan-1-amine 
• 1296865-62-7 3-(1-benzyl-1H-tetrazol-5-ylthio)-N,N-di-n-propylpropan-1-amine 
• 1296865-69-4 5-[3-(1-benzyl-1H-tetrazol-5-ylthio)propylthio]-4-(2,5-dichlorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 

Relevant academic research and scientific papers

Mechanism of the zinc-catalyzed addition of azide ion to unsaturated compounds: Synthesis of 5-substituted 1Н-tetrazoles from nitriles and of 1-substituted 1Н-tetrazole-5-thiols from isothiocyanates

The mechanism of the formation of 5-substituted 1H-tetrazoles from organic nitriles and thiocyanates in the presence of NaN3 and ZnCl2 in aliphatic alcohols was studied. The results of this study allowed efficient methods of synthesis of substituted tetrazoles from nitriles, thiocyanates, and isothiocyanates to be proposed.

Reactions of dimethyl 2-chloroethynylphosphonate with 1-substituted 5-oxo-1H-1,2,3,4-tetrazoles

Addition of 1-substituted tetrazol-5-ones to dimethyl 2-chloroethynylphosphonate occurred regioselectively to form new geminally substituted bis(4-R-5-oxo-4,5-dihydro-1H-tetrazol-1-yl)ethenylphosphonates with 65- 92% yield.

A facile one-pot synthesis of 1-substituted tetrazole-5-thiones and 1-substituted 5-alkyl(aryl)sulfanyltetrazoles from organic isothiocyanates

Treatments of organic isothiocyanates (R-NCS) with NaN3 in the presence of pyridine in water at room temperature gave corresponding various organic tetrazole-thiones, [S=CN4(R)] (R = alkyl or aryl). Isolated products are obtained as white or yellow solids in good yields (76-97%). The molecular structure by X-ray diffraction study for one of products shows the proposed formation. In addition, one-pot synthesis of 1- substituted 5-alkyl(or aryl)sulfanyltetrazoles has been demonstrated. Addition of alkyl or aryl halides into the mixture of organic isothiocyanates, NaN3, and pyridine in water at room temperature exclusively formed 1- substituted 5-alkyl(or aryl)sulfanyltetrazoles (S-derivatives) in high yields.

Synthesis of selected 5-thio-substituted tetrazole derivatives and evaluation of their antibacterial and antifungal activities

Several 5-thio-substituted tetrazole derivatives were efficiently synthesized by a three-step process. The substituted tetrazol-5-thiol, namely, 1-benzyl-1H-tetrazole-5-thiol (2) was prepared by refluxing commercially available benzyl isothiocyanate (1) w

Dopamine-β-hydroxylase inhibitors and use thereof

The compounds of this invention are 1-phenylalkyl-2-mercaptotetrazole compounds which are dopamine-β-hydroxylase inhibitors.