6392-77-4

Basic information

• Product Name: BENZYL-DITHIOCARBAMIC ACID METHYL ESTER
• Synonyms: BENZYL-DITHIOCARBAMIC ACID METHYL ESTER;AKOS BBS-00007085
• CAS NO: 6392-77-4
• Molecular Formula: C₉H₁₁NS₂
• Molecular Weight: 197.32034
• Mol File: 6392-77-4.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 310.2°C at 760 mmHg
• Flash Point: 141.4°C
• Appearance: /
• Density: 1.184g/cm³
• Vapor Pressure: 0.000611mmHg at 25°C
• Refractive Index: 1.63
• CAS DataBase Reference: BENZYL-DITHIOCARBAMIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: BENZYL-DITHIOCARBAMIC ACID METHYL ESTER(6392-77-4)
• EPA Substance Registry System: BENZYL-DITHIOCARBAMIC ACID METHYL ESTER(6392-77-4)

Safety Data

• Hazardous Substances Data: 6392-77-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H11NS2/c1-12-9(11)10-7-8-5-3-2-4-6-8/h2-6H,7H2,1H3,(H,10,11)

Upstream product

• 5115-14-0 monobenzyldithiocarbamate sodium 
• 77-78-1 dimethyl sulfate 
• 100-46-9 benzylamine 
• 75-15-0 carbon disulfide 
• 80-48-8 methyl p-toluene sulfonate 
• 74734-11-5 1H-imidazole-1-carbodithioic acid methyl ester 
• 622-78-6 Benzyl isothiocyanate 
• 5188-07-8 sodium thiomethoxide 
• 2314-48-9 (S,S)-dimethyl trithiocarbonate 
• 74-88-4 methyl iodide 

Downstream Products

• 33898-72-5 1-benzyl-1H-tetrazole-5(4H)-thione 
• 74395-78-1 3-benzyl-2-hydrazino-3H-quinazolin-4-one 
• 77437-24-2 C₂₃H₂₁N₅OS 
• 1688-81-9 3-benzyl-2-(methylsulphanyl)-3H-quinazolin-4-one 
• 77437-22-0 C₂₂H₁₉N₅OS 
• 1318765-15-9 1-isatin-4-benzyl-3-thiosemicarbazone 
• 13431-41-9 4-benzylthiosemicarbazide 

Relevant articles and documents

Macahydantoins A and B, two new thiohydantoin derivatives from Maca (Lepidium meyenii): Structural elucidation and concise synthesis of macahydantoin A

Macahydantoins A (1) and B (2), two new thiohydantoin derivatives with an unprecedented skeleton, were isolated from maca (Lepidium meyenii). Their structures and absolute configurations were fully established by extensive spectroscopic and computational methods. The totally chemical synthesis of macahydantoin A was achieved via benzylamine and methyl piperidine-3-carboxylate hydrochloride through nucleophilic addition and intramolecular dehydration condensation.

Synthesis and in vitro bio-activity evaluation of N4-benzyl substituted 5-chloroisatin- 3-thiosemicarbazones as urease and glycation inhibitors

A series of fifteen N4-benzyl substituted 5-chloroisatin-3-thiosemicarbazones 5a-o were synthesized and screened mainly for their antiurease and antiglycation effects. Lemna aequinocitalis growth and Artemia salina assays were carried out to de

Antimicrobial activities of some synthesized 1-(3-(2-methylphenyl)-4-Oxo-3H-quinazolin-2-yl-4-(substituted)thiosemicarbazide derivatives

The substituted thiosemicarbazide moiety was placed at the C-2 position and 2-methylphenyl group at N-3 position of quinazoline ring and obtained compounds were tested for their antitubercular activities and antibacterial activities against selected gram-positive and gram-negative bacteria. The target compounds 1-(3-(2-methylphenyl)-4-oxo-3H-quinazolin-2-yl)-4-(substituted) thiosemicarbazides were obtained by the reaction of 2-hydrazino-3-(2-methylphenyl) quinazolin-4(3H)-one with different dithiocarbamic acid methyl ester derivatives. All synthesized compounds were also screened for their antimicrobial activity against selective gram-positive and gram-negative bacteria by agar dilution method. Among the series, 1-[3-(2-methylphenyl)-4-oxo-3H-quinazolin-2-yl]-4-[4-chlorophenyl]-thiosemicarbazide exhibited the most potent activity against S. typhi, E. coli, and B. subtilis, while 1-[3-(2-methylphenyl)-4-oxo-3H-quinazolin-2-yl]-4-[4-nitrophenyl]-thiosemicarbazide was the most potent against E. coli, B. subtilis, P. aeruginosa, S. typhi, and S. flexneri. These two compounds exhibited the antitubercular activity at the minimum concentration (3 μg/mL) that offered potential for further optimization and development of new antitubercular agents. The obtained results demonstrated promising antimicrobial and antitubercular activities of the synthesized quinazoline compounds which could be used as new scaffolds for improving their antimicrobial activity.