33899-44-4

Upstream product

• 21524-17-4 5,7-diacetoxyl-2-chromenone 
• 870-63-3 prenyl bromide 
• 2732-18-5 5,7-dihydroxy-2H-chromen-2-one 
• 59036-52-1 5-(3'-methyl-2'-butenyloxy)-7-(1,1-dimethyl-2-propynyloxy)coumarin 
• 59036-54-3 5-(3'-methyl-2'-butenyloxy)-7-(1,1-dimethyl-2-propenyloxy)coumarin 
• 59036-51-0 7-acetoxy-5-(3'-methyl-2'-butenyloxy)coumarin 

Downstream Products

• 62395-58-8 hortiolone 
• 85657-31-4 5-(3-methylbut-2-enyl)oxyoroselone 
• 35590-41-1 5-(isopent-2'-enyloxy)-7-methoxycoumarin 

Relevant academic research and scientific papers

New coumarins from Citrus plants

Four new coumarins, named peroxytamarin (1), cis-casegravol (5), citrusarin-A (7), and citrusarin-B (8), were isolated from root of Citrus plants and their structures were elucidated by chemical and spectrometric methods. Citrusarin-B (8), a coumarin having both a dimethylpyran ring and a dihydrofuran ring in the molecule, was also synthesized.

SYNTHESIS OF (+/-)-5-HYDROXYMARMESIN: BIOGENETIC PRECURSOR OF THE SKIN PHOTOSENSITIZING AGENT BERGAPTEN

The synthesis of (+/-)-5-hydroxymarmesin is described.The 5,7-diacetoxycoumarin was selectively C(8) isoprenylated, the isoprenylated intermediate underwent oxidative cyclization to (+/-)-5-hydroxycolumbianetin, which was transformed into (+/-)-5-hydroxymarmesin by alkali treatment.Preliminary experiments showed that this compound has a biogenetic role in the biogenesis of the skin photosensitizing agent bergapten (5-MOP).