339007-88-4

Basic information

• Product Name: 1-[(TERT-BUTOXY)CARBONYL]-2,3-DIHYDRO-1H-INDOLE-5-CARBOXYLIC ACID
• Synonyms: 1-[(TERT-BUTOXY)CARBONYL]-2,3-DIHYDRO-1H-INDOLE-5-CARBOXYLIC ACID;1-(tert-butoxycarbonyl)indoline-5-carboxylic acid;1H-INDOLE-1,5-DICARBOXYLIC ACID,2,3-DIHYDRO-,1-(1,1-DIMETHYLETHYL)ESTER
• CAS NO: 339007-88-4
• Molecular Formula: C14H17NO4
• Molecular Weight: 263.28908
• Mol File: 339007-88-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 421.0±44.0 °C(Predicted)
• Appearance: /
• Density: 1.257±0.06 g/cm3(Predicted)
• PKA: 4.46±0.20(Predicted)
• CAS DataBase Reference: 1-[(TERT-BUTOXY)CARBONYL]-2,3-DIHYDRO-1H-INDOLE-5-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(TERT-BUTOXY)CARBONYL]-2,3-DIHYDRO-1H-INDOLE-5-CARBOXYLIC ACID(339007-88-4)
• EPA Substance Registry System: 1-[(TERT-BUTOXY)CARBONYL]-2,3-DIHYDRO-1H-INDOLE-5-CARBOXYLIC ACID(339007-88-4)

Safety Data

• Hazardous Substances Data: 339007-88-4(Hazardous Substances Data)

Usage

Chemical structure

The compound has a complex structure consisting of an indole core attached to a carboxylic acid group and a tert-butoxy carbonyl group.

Functional groups

The compound contains an indole core, a carboxylic acid group, and a tert-butoxy carbonyl group.

Applications

It is commonly used in organic synthesis and pharmaceutical research.

Potential uses

The compound may have potential applications in the development of new drugs or materials.

Versatility

The compound's unique structure and functional groups make it a versatile building block for the synthesis of more complex molecules and materials.

Interest for further study

Its properties and potential uses make it an interesting target for further study and development.

Molecular weight

The molecular weight of the compound is approximately 259.29 g/mol.

Upstream product

• 261732-38-1 tert-butyl 5-bromoindoline-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 15861-30-0 2,3-dihydro-1H-indole-5-formic acid 
• 7646-93-7 potassium hydrogensulfate 
• 272438-12-7 1-tert-butyl 5-methyl indoline-1,5-dicarboxylate 

Relevant articles and documents

COMPOUNDS FOR TREATMENT OF CANCER AND EPIGENETICS

The present invention relates to heterocyclic compounds having the general Formula (I) wherein W1, W2, W3, W4, W7, W8, R1, R2, R3, R4, X2, X3, X4, Z1, Z2, Z3, Q, n and m are as defined herein, or a pharmaceutically acceptable salt thereof, wherein the compound is useful for treating SMYD3- related cancer.

AMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1

Compounds of the formula (I) provide pharmacological agents which lower intracellular glucocorticoid concentrations in mammals, in particular, intracellular cortisol levels in humans. Therefore, the compounds of the instant invention improve insulin sensitivity in the muscle and the adipose tissue, and reduce lipolysis and free fatty acid production in the adipose tissue. The compounds of the invention lower hepatic glucocorticoid concentration in mammals, in particular, hepatic cortisol concentration in humans, resulting in inhibition of hepatic gluconeogenesis and lowering of plasma glucose levels. Thus, the compounds of the instant invention may be particularly useful in mammals as hypoglycemic agents for the treatment and prevention of conditions in which hyperglycemia and/or insulin resistance are implicated, such as type-2 diabetes. The compounds of the invention may also be used to treat other glucocorticoid associated disorders, such as Syndrome-X, dyslipidemia, hypertension and central obesity. The invention furthermore relates to the use of the compounds according to the invention for the preparation of medicaments, in particular of medicaments useful for the treatment and prevention of glucocorticoid associated disorders, by improving insulin sensitivity, reducing plasma glucose levels, reducing lipolysis and free fatty acid production, and by decreasing visceral adipose tissue formation.