339017-83-3Relevant academic research and scientific papers
Discovery of High-Affinity Inhibitors of the BPTF Bromodomain
Lu, Tian,Lu, Haibo,Duan, Zhe,Wang, Jun,Han, Jie,Xiao, Senhao,Chen, HuanHuan,Jiang, Hao,Chen, Yu,Yang, Feng,Li, Qi,Chen, Dongying,Lin, Jin,Li, Bo,Jiang, Hualiang,Chen, Kaixian,Lu, Wenchao,Lin, Hua,Luo, Cheng
, p. 12075 - 12088 (2021/09/02)
The dysfunctional bromodomain PHD finger transcription factor (BPTF) exerts a pivotal influence in the occurrence and development of many human diseases, particularly cancers. Herein, through the structural decomposition of the reported BPTF inhibitor TP-
NEW PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS (PDE-10)
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Page/Page column 31; 32, (2014/08/07)
The present invention relates to novel pyrimidine derivatives of formula (I)[Formula should be entered here] as inhibitors of the enzyme phosphodiesterase 10 (PDE-10), pharmaceutical compositions comprising an effective amount of these compoundsand theuse of the compounds for manufacturing a medicamentfor thetreatment ofpathological conditions or diseases that can improve by inhibition of the enzyme Phosphodiesterase such as neurological, psychiatric, respiratory or metabolic diseases.
Identification of aminopyrimidine regioisomers via line broadening effects in1H and13C NMR spectroscopy
Garner, James,Hill, Tim,Odell, Luke,Keller, Paul,Morgan, Jody,McCluskey, Adam
, p. 1079 - 1083 (2007/10/03)
Substituted mono- and diamino-pyrimidines were synthesized as part of our medicinal chemistry programmes. Primary amines substituted at the 4-position exhibited room-temperature line broadening effects in both 1H and 13C NMR spectros
