339079-97-9Relevant academic research and scientific papers
Nucleophilic addition to the exocylic double bond of 5-substituted 2-thioxo-4-oxothiazolidines
Omar,Youssef,Nessim
, p. 75 - 92 (2007/10/03)
THE REACTIVITY of the exocyclic double bond at position-5 of the 2-thioxo-4-oxothiazolidine ring system towards the addition of nucleophiles has been studied, aiming to synthesize spiro benzothiazolothiazoles 5, benzothiazines 8 and benzopyrazines 13 deri
A one-pot synthesis of 2,3-dihydro-2-thioxothieno[2,3-d]thiazoles
Omar,El-Aasar,Saied
, p. 413 - 418 (2007/10/03)
A variety of 3,5-disubstituted-2,3-dihydro-2-thioxothieno[2,3-d]thiazoles 3a-h including alkyl-, aryl- and heteryl- substituents were synthesized in excellent yields in a one pot re-action between 3-substituted-5-(2-aryl (or heteryl)-2-oxoethyl)-4-oxo-2-thioxo-1,3-thiazolidines 1a-h and either tetraphosphorous decasulfide (Method A) or Lawesson's reagent (Method B). However, fair yields of 3 were also obtained along with unknown oily products when the (E,Z)-5-(2-aryl-2-oxoethylidene) derivatives 2f, g were similarly treated with the same reagents. Structures of products were supported by microanalytical and spectral evidence. A rationalization for the route of conversion is given.
