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339183-92-5

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339183-92-5 Usage

Uses

Benzyl (+/-)-trans-N-boc-4-methyl-piperidine-2-carboxylate is Used in the synthesis of Argatroban (A769000).

Check Digit Verification of cas no

The CAS Registry Mumber 339183-92-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,3,9,1,8 and 3 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 339183-92:
(8*3)+(7*3)+(6*9)+(5*1)+(4*8)+(3*3)+(2*9)+(1*2)=165
165 % 10 = 5
So 339183-92-5 is a valid CAS Registry Number.

339183-92-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-O-benzyl 1-O-tert-butyl (2S,4S)-4-methylpiperidine-1,2-dicarboxylate

1.2 Other means of identification

Product number -
Other names trans-2-Benzyl 1-tert-butyl 4-methylpiperidine-1,2-dicarboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:339183-92-5 SDS

339183-92-5Downstream Products

339183-92-5Relevant articles and documents

Efficient Diastereoselective Three-Component Synthesis of Pipecolic Amides

van der Heijden, Gydo,van Schaik, Timo B.,Mouarrawis, Valentinos,de Wit, Martin J. M.,Velde, Christophe M. L. Vande,Ruijter, Eelco,Orru, Romano V. A.

, p. 5313 - 5325 (2019/06/10)

An efficient Ugi-type three-component reaction (U-3CR) for the synthesis of pipecolic amides is reported. The U-3CR between electronically diverse isocyanides, carboxylic acids and 4-substituted Δ1-piperideines proceeds in a highly diastereoselective fashion. The Δ1-piperideines are obtained by NCS-mediated oxidation of the corresponding 4-substituted piperidines, which in turn are generated by an efficient two-step procedure involving the alkylation of 4-picoline and subsequent catalytic hydrogenation of the pyridine ring. We demonstrate the utility of this U-3CR, in combination with the convertible isocyanide 2-bromo-6-isocyanopyridine, in the synthesis of the anticoagulant argatroban.

A short synthesis of argatroban: A potent selective thrombin inhibitor

Cossy, Janine,Belotti, Damien

, p. 1989 - 1992 (2007/10/03)

Argatroban was synthesized in seven steps from 4-methylpiperidine. The condensation of (±)-trans-benzyl 4-methylpipecolic acid ester with Nα-Boc-Nω-nitro-L-arginine led to two diastereomers that were separated. One of them is the precursor of argatroban.

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