339185-84-1Relevant academic research and scientific papers
Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile
Ripa, Lena,Edman, Karl,Dearman, Matthew,Edenro, Goran,Hendrickx, Ramon,Ullah, Victoria,Chang, Hui-Fang,Lepist?, Matti,Chapman, Dave,Geschwindner, Stefan,Wissler, Lisa,Svanberg, Petter,Lawitz, Karolina,Malmberg, Jesper,Nikitidis, Antonios,Olsson, Roine I.,Bird, James,Llinas, Antoni,Hegelund-Myrb?ck, Tove,Berger, Markus,Thorne, Philip,Harrison, Richard,K?hler, Christian,Drmota, Tomas
supporting information, p. 1785 - 1799 (2018/03/21)
Synthetic glucocorticoids (GC) are essential for the treatment of a broad range of inflammatory diseases. However, their use is limited by target related adverse effects on, e.g., glucose homeostasis and bone metabolism. Starting from a nonsteroidal GR li
Peptide fragment coupling using a continuous-flow photochemical rearrangement of nitrones
Zhang, Yuan,Blackman, Melissa L.,Leduc, Andrew B.,Jamison, Timothy F.
supporting information, p. 4251 - 4255 (2013/05/08)
Go with the flow: A general approach for amide bond formation by way of a continuous-flow photochemical rearrangement of nitrones was described (see scheme). Simple aryl-alkyl amide bonds as well as complex peptide bonds were constructed efficiently with a residence time less than 20minutes. A tetrapeptide was synthesized in this way and the method could be applied to peptide fragment coupling. Copyright
