339209-03-9Relevant academic research and scientific papers
The design of phenylglycine containing benzamidine carboxamides as potent and selective inhibitors of factor Xa
Jones, Stuart D,Liebeschuetz, John W,Morgan, Phillip J,Murray, Christopher W,Rimmer, Andrew D,Roscoe, Jonathan M.E,Waszkowycz, Bohdan,Welsh, Pauline M,Wylie, William A,Young, Stephen C,Martin, Harry,Mahler, Jacqui,Brady, Leo,Wilkinson, Kay
, p. 733 - 736 (2007/10/03)
Factor Xa. a critical serine protease in the blood coagulation cascade, has become a target for inhibition as a strategy for the invention of novel anti-thrombotic agents. Here we describe the development of phenylglycine containing benzamidine carboxamides as novel, potent and selective inhibitors of factor Xa.
