33922-96-2

Usage

Uses

Used in Pharmaceutical Industry:
CHEMBRDG-BB 9038439 is used as a potential anti-cancer agent for its inhibitory activity against various cancer cell lines. It is being explored for its potential to treat different types of cancer by targeting and inhibiting the growth and proliferation of cancer cells.
CHEMBRDG-BB 9038439 is also used as a potential anti-inflammatory agent due to its demonstrated anti-inflammatory properties. It may be utilized in the development of new drugs to treat various inflammatory conditions by reducing inflammation and associated symptoms.
Further research is required to fully understand the potential applications and mechanisms of action of CHEMBRDG-BB 9038439, which could lead to its incorporation into novel drug formulations and therapeutic strategies in the pharmaceutical industry.

InChI:InChI=1/C9H10BrNO2/c1-11-8-4-3-6(10)5-7(8)9(12)13-2/h3-5,11H,1-2H3

Upstream product

• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 74-88-4 methyl iodide 
• 851314-03-9 methyl 5-bromo-2-((tert-butoxycarbonyl)amino)benzoate 
• 67-56-1 methanol 
• 22721-17-1 6-bromo-1-methyl-2H-benzo[d][1,3]oxazine-2,4(1H)-dione 

Relevant academic research and scientific papers

Total synthesis of acronycine and noracronycine: An aryne amination approach

Acronycine and noracronycine are chromene-containing alkaloids with significant biological activity. We have accomplished a concise total synthesis of acronycine and noracronycine. The key step, regioselective nucleophilic addition of anthranilate to chromene-type arynes under mild and transition-metal-free conditions was achieved. In addition, further modifications of nucleophilic addition products, such as hydrogenation, O-functionalization and palladium-catalyzed coupling reactions have also been developed, providing a concise procedure for these alkaloids and their derivatives.

Scaffold Hopping of Natural Product Evodiamine: Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer

Inspired by the natural product evodiamine, a novel antitumor indolopyrazinoquinazolinone scaffold was designed by scaffold hopping. Structure-activity relationship studies led to the discovery of compound 15j, which shows low nanomolar inhibitory activity against the HCT116 cell line. Further antitumor mechanism studies indicated that compound 15j acted by the dual inhibition of topoisomerase 1 and tubulin and induced apoptosis with G2 cell-cycle arrest. The quaternary ammonium salt of compound 15j (compound 15js) exhibited excellent in vivo antitumor activity (TGI = 66.6%) in the HCT116 xenograft model with low toxicity. Indolopyrazinoquinazolinone derivatives represent promising multitargeting antitumor leads for the development of novel antitumor agents.

Synthesis of xanthones, thioxanthones, and acridones by the coupling of arynes and substituted benzoates

The reaction of silylaryl triflates, CsF, and ortho-heteroatom-substituted benzoates affords a general and efficient way to prepare biologically interesting xanthones, thioxanthones, and acridones. This chemistry presumably proceeds by a tandem intermolecular nucleophilic coupling of the benzoate with an aryne and a subsequent intramolecular electrophilic cyclization.