33924-54-8

Basic information

• Product Name: 4-(2-(5-CHOLRO-2-METHOXY BENZAMIDO)ETHYL)BENZENESULFONYL CHLORIDE
• Synonyms: 4-(2-(5-CHOLRO-2-METHOXY BENZAMIDO)ETHYL)BENZENESULFONYL CHLORIDE;4-(2-(5-Chloro-2-methoxy benzamido)ethyl)benzenesulfonyl chloride p-(2-(5-Chloro-o-anisamido)ethyl)benzenesulfonyl chloride;4-(2-(5-chloro-2-methoxybenzamido)ethyl)benzenesulfonyl chloride
• CAS NO: 33924-54-8
• Molecular Formula: C₁₆H₁₅Cl₂NO₄S
• Molecular Weight: 388.2656
• Mol File: 33924-54-8.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 537.3°C at 760 mmHg
• Flash Point: 278.7°C
• Appearance: /
• Density: 1.388g/cm³
• Vapor Pressure: 1.29E-11mmHg at 25°C
• Refractive Index: 1.586
• CAS DataBase Reference: 4-(2-(5-CHOLRO-2-METHOXY BENZAMIDO)ETHYL)BENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-(5-CHOLRO-2-METHOXY BENZAMIDO)ETHYL)BENZENESULFONYL CHLORIDE(33924-54-8)
• EPA Substance Registry System: 4-(2-(5-CHOLRO-2-METHOXY BENZAMIDO)ETHYL)BENZENESULFONYL CHLORIDE(33924-54-8)

Safety Data

• Hazardous Substances Data: 33924-54-8(Hazardous Substances Data)

Usage

General Description

4-(2-(5-CHOLRO-2-METHOXY BENZAMIDO)ETHYL)BENZENESULFONYL CHLORIDE is a chemical compound that consists of a benzene ring attached to a sulfonyl chloride group and a 2-(5-chloro-2-methoxy benzamido)ethyl group. It is primarily used in the synthesis of pharmaceutical compounds and agrochemicals as a reagent. 4-(2-(5-CHOLRO-2-METHOXY BENZAMIDO)ETHYL)BENZENESULFONYL CHLORIDE is a reactive intermediate and is particularly useful in the development of new drugs and agrochemicals due to its ability to modify the structure of organic molecules. It is also used in the manufacturing of dyes, pigments, and other specialty chemicals. Additionally, it is important to handle this compound with care as it is corrosive, toxic, and can cause severe skin and eye irritation.

InChI:InChI=1/C16H15Cl2NO4S/c1-23-15-7-4-12(17)10-14(15)16(20)19-9-8-11-2-5-13(6-3-11)24(18,21)22/h2-7,10H,8-9H2,1H3,(H,19,20)

Upstream product

• 16673-34-0 5-chloro-2-methoxy-N-(4-sulfamoylphenethyl)benzamide 
• 29568-33-0 2-methoxy-5-chlorobenzoyl chloride 
• 33924-49-1 DK₁₃ 
• 64-04-0 phenethylamine 
• 3438-16-2 5-chloro-2-methoxybenzoic acid 

Downstream Products

• 16673-34-0 5-chloro-2-methoxy-N-(4-sulfamoylphenethyl)benzamide 
• 33924-53-7 4-[2-(5-Chloro-2-methoxy-benzoylamino)-ethyl]-benzenesulfonic acid 
• 10238-21-8 Glibenclamid 

Relevant articles and documents

Intermolecular C-H Amidation of Alkenes with Carbon Monoxide and Azides via Tandem Palladium Catalysis

An atom- and step-economic intermolecular multi-component palladium-catalyzed C-H amidation of alkenes with carbon monoxide and organic azides has been developed for the synthesis of alkenyl amides. The reaction proceeds efficiently without an ortho -directing group on the alkene substrates. Nontoxic dinitrogen is generated as the sole by-product. Computational studies and control experiments have revealed that the reaction takes place via an unexpected mechanism by tandem palladium catalysis.

Selective Late-Stage Sulfonyl Chloride Formation from Sulfonamides Enabled by Pyry-BF4

Reported here is a simple and practical functionalization of primary sulfonamides, by means of a pyrylium salt (Pyry-BF4), with nucleophiles. This simple reagent activates the poorly nucleophilic NH2 group in a sulfonamide, enabling the formation of one of the best electrophiles in organic synthesis: a sulfonyl chloride. Because of the variety of primary sulfonamides in pharmaceutical contexts, special attention has been focused on the direct conversion of densely functionalized primary sulfonamides by a late-stage formation of the corresponding sulfonyl chloride. A variety of nucleophiles could be engaged in this transformation, thus permitting the synthesis of complex sulfonamides, sulfonates, sulfides, sulfonyl fluorides, and sulfonic acids. The mild reaction conditions and the high selectivity of Pyry-BF4 towards NH2 groups permit the formation of sulfonyl chlorides in a late-stage fashion, tolerating a preponderance of sensitive functionalities.

N-HYDROXY-BENZENE-SULFONAMIDE DERIVATIVES AND THEIR USES THEREOF

Inhibitors with anti-inflammatory agents are provided, as are methods of using the analogs to inhibit inflammation and prevent or treat diseases and conditions associated with inflammation, such as multiple sclerosis and autoinflammatory diseases.