29568-33-0

Basic information

• Product Name: 5-CHLORO-2-METHOXYBENZOYL CHLORIDE
• Synonyms: 5-CHLORO-2-METHOXYBENZOYL CHLORIDE;2-METHOXY-5-CHLOROBENZOYLCHLORIDE;O-METHOXY-5-CHLOROBENZOYLCHLORIDE
• CAS NO: 29568-33-0
• Molecular Formula: C₈H₆Cl₂O₂
• Molecular Weight: 205.04
• Mol File: 29568-33-0.mol

Chemical Properties

• Boiling Point: 284.169°C at 760 mmHg
• Flash Point: 124.353°C
• Appearance: /
• Density: 1.351g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.546
• CAS DataBase Reference: 5-CHLORO-2-METHOXYBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-2-METHOXYBENZOYL CHLORIDE(29568-33-0)
• EPA Substance Registry System: 5-CHLORO-2-METHOXYBENZOYL CHLORIDE(29568-33-0)

Safety Data

• Hazardous Substances Data: 29568-33-0(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
5-Chloro-2-methoxybenzoyl chloride is used as a reagent for the preparation of other chemicals or compounds. Its reactivity, due to the presence of the chloride group, makes it a key component in the formation of various benzoyl derivatives.
Used in Pharmaceutical Industry:
5-Chloro-2-methoxybenzoyl chloride is used as an intermediate in the synthesis of pharmaceutical compounds. Its ability to form benzoyl derivatives is crucial in creating new drug molecules with potential therapeutic applications.
Used in Research and Development:
5-Chloro-2-methoxybenzoyl chloride is used as a research compound for studying chemical reactions and exploring new synthetic pathways. Its reactivity and versatility make it a valuable tool in the development of novel chemical entities.
Used in Material Science:
5-Chloro-2-methoxybenzoyl chloride is used as a precursor in the development of new materials with specific properties. Its role in the synthesis of benzoyl derivatives can contribute to the creation of advanced materials for various applications, such as electronics or coatings.

InChI:InChI=1/C8H6Cl2O2/c1-12-7-3-2-5(9)4-6(7)8(10)11/h2-4H,1H3

Upstream product

• 3438-16-2 5-chloro-2-methoxybenzoic acid 
• 33924-48-0 methyl 5-chloro-2-methoxybenzoate 
• 79-37-8 oxalyl dichloride 
• 55877-79-7 2-methoxy-5-chlorobenzonitrile 
• 321-14-2 5-chloro-2-hydroxybenzoic acid 

Downstream Products

• 94843-66-0 5-Chloro-N-(4,6-dimethyl-pyridin-2-yl)-2-methoxy-benzamide 
• 193882-52-9 5-chloro-2-methoxy-N-(1-azabicyclo<2.2.2>oct-3-yl)benzamide 
• 202822-39-7 5-Chloro-2-methoxy-N-[4-(trifluoromethyl)phenyl]benzamide 
• 424809-43-8 5-chloro-2-methoxy-N-(4-methyl-2-nitro-phenyl)-benzamide 
• 349434-79-3 5-chloro-2-methoxy-N-(2-methoxy-4-nitro-phenyl)-benzamide 
• 594854-55-4 {4-[2-(5-chloro-2-methoxybenzamido)ethyl]phenyl} phosphate 
• 3261-05-0 5-chlorobenzofuran-3(2H)-one 
• 854195-21-4 3-[2-(5-chloro-2-methoxy-phenyl)-5-trifluoromethyl-pyrrol-1-yl]-benzoic acid ethyl ester 
• 854195-23-6 3-[2-(5-chloro-2-hydroxy-phenyl)-5-trifluoromethyl-pyrrol-1-yl]-benzoic acid 
• 854195-11-2 3-[2-(5-chloro-2-methoxy-phenyl)-pyrrol-1-yl]-benzoic acid ethyl ester 
• 959749-16-7 N-(5-tert-butylthiazol-2-yl)-5-chloro-2-methoxybenzamide 

Relevant articles and documents

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Over the past few decades, an increasing variety of molecular chaperones have been investigated for their role in tumorigenesis and as potential chemotherapeutic targets; however, the 60 kDa Heat Shock Protein (HSP60), along with its HSP10 co-chaperone, have received little attention in this regard. In the present study, we investigated two series of our previously developed inhibitors of the bacterial homolog of HSP60/10, called GroEL/ES, for their selective cytotoxicity to cancerous over non-cancerous colorectal cells. We further developed a third “hybrid” series of analogs to identify new candidates with superior properties than the two parent scaffolds. Using a series of well-established HSP60/10 biochemical screens and cell-viability assays, we identified 24 inhibitors (14%) that exhibited > 3-fold selectivity for targeting colorectal cancer over non-cancerous cells. Notably, cell viability EC50 results correlated with the relative expression of HSP60 in the mitochondria, suggesting a potential for this HSP60-targeting chemotherapeutic strategy as emerging evidence indicates that HSP60 is up-regulated in colorectal cancer tumors. Further examination of five lead candidates indicated their ability to inhibit the clonogenicity and migration of colorectal cancer cells. These promising results are the most thorough analysis and first reported instance of HSP60/10 inhibitors being able to selectively target colorectal cancer cells and highlight the potential of the HSP60/10 chaperonin system as a viable chemotherapeutic target.

Palladium-Catalyzed 5-exo-dig Cyclization Cascade, Sequential Amination/Etherification for Stereoselective Construction of 3-Methyleneindolinones

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Intermolecular C-H Amidation of Alkenes with Carbon Monoxide and Azides via Tandem Palladium Catalysis

An atom- and step-economic intermolecular multi-component palladium-catalyzed C-H amidation of alkenes with carbon monoxide and organic azides has been developed for the synthesis of alkenyl amides. The reaction proceeds efficiently without an ortho -directing group on the alkene substrates. Nontoxic dinitrogen is generated as the sole by-product. Computational studies and control experiments have revealed that the reaction takes place via an unexpected mechanism by tandem palladium catalysis.

Synthesis and antioxidant activities of berberine 9-: O -benzoic acid derivatives

Although berberine (BBR) shows antioxidant activity, its activity is limited. We synthesized 9-O-benzoic acid berberine derivatives, and their antioxidant activities were screened via ABTS, DPPH, HOSC and FRAP assays. The para-position was modified with halogen elements on the benzoic acid ring, which led to an enhanced antioxidant activity and the substituent on the ortho-position was found to be better than the meta-position. Compounds 8p, 8c, 8d, 8i, 8j, 8l, and especially 8p showed significantly higher antioxidant activities, which could be attributed to the electronic donating groups. All the berberine derivatives possessed proper lipophilicities. In conclusion, compound 8p is a promising antioxidant candidate with remarkable elevated antioxidant activity and moderate lipophilicity.

Palladium-catalyzed cascade decarboxylative amination/6- endo-dig benzannulation of o-alkynylarylketones with n-hydroxyamides to access diverse 1-naphthylamine derivatives

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Discovery and Structure Relationships of Salicylanilide Derivatives as Potent, Non-acidic P2X1 Receptor Antagonists

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Pd-catalyzed amidation of 1,3-diketones with CO and azidesviaa nitrene intermediate

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Design, synthesis, and preliminary biological evaluation of 3′,4′,5′-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents

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Synthesis of Functionalized Ketones from Acid Chlorides and Organolithiums by Extremely Fast Micromixing

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SUBSTITUTED PYRROLIDINES AND THEIR USE

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