339246-36-5Relevant academic research and scientific papers
Rational design, synthesis and structure-activity relationships of 4-alkoxy- and 4-acyloxy-phenylethylenethiosemicarbazone analogues as novel tyrosinase inhibitors
You, Ao,Zhou, Jie,Song, Senchuan,Zhu, Guoxun,Song, Huacan,Yi, Wei
, p. 924 - 931 (2015/03/04)
In continuing our program aimed to search for potent compounds as highly efficient tyrosinase inhibitors, here a series of novel 4-alkoxy- and 4-acyloxy-phenylethylenethiosemicarbazone analogues were designed, synthesized and their biological activities on mushroom tyrosinase were evaluated. Notably, most of compounds displayed remarkable tyrosinase inhibitory activities with IC50 value of lower than 1.0 μM. Furthermore, the structure-activity relationships (SARs) were discussed and the inhibition mechanism and the inhibitory kinetics of selected compounds 7k and 8d were also investigated. Taken together, these results suggested that such compounds could serve as the promising candidates for the treatment of tyrosinase-related disorders and further development of such compounds might be of great interest.
A class of potent tyrosinase inhibitors: Alkylidenethiosemicarbazide compounds
Liu, Jinbing,Cao, Rihui,Yi, Wei,Ma, Chunming,Wan, Yiqian,Zhou, Binhua,Ma, Lin,Song, Huacan
experimental part, p. 1773 - 1778 (2009/05/26)
A series of alkylidenethiosemicarbazide compounds were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were evaluated. The results showed that most of the synthesized compounds exhibited significant inhibitory activities. Especially, compound 1f was found to be the most potent inhibitor with IC50 value of 0.086 μM, suggesting that further development of such compounds may be of interest.
1-(1-Arylethylidene)thiosemicarbazide derivatives: A new class of tyrosinase inhibitors
Liu, Jinbing,Yi, Wei,Wan, Yiqian,Ma, Lin,Song, Huacan
, p. 1096 - 1102 (2008/09/18)
A series of 1-(1-arylethylidene)thiosemicarbazide compounds and their analogues were synthesized and characterized by 1H NMR, MS. Their tyrosinase inhibitory activities were investigated by an assay based on the catalyzing ability of tyrosinase
