339530-91-5

Basic information

• Product Name: 3-[(4-Fluorophenyl)thio]-2-hydroxy-2-methylpropanoic acid
• Synonyms: 3-(4-FLUOROPHENYLTHIO)-2-HYDROXY-2-METHYLPROPANOIC ACID;3-(4-Fluobenzenesulfhydryl)-2-;3-(4-Fluorobenzensulfydryl)-2-hydroxyl-2-methylpropionic acid（ForBicalutamide）
• CAS NO: 339530-91-5
• Molecular Formula: C₁₀H₁₁FO₃S
• Molecular Weight: 230.26
• Product Categories: Bicalutamide
• Mol File: 339530-91-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 392.121 °C at 760 mmHg
• Flash Point: 190.948 °C
• Appearance: /
• Density: 1.376 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: 3-[(4-Fluorophenyl)thio]-2-hydroxy-2-methylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[(4-Fluorophenyl)thio]-2-hydroxy-2-methylpropanoic acid(339530-91-5)
• EPA Substance Registry System: 3-[(4-Fluorophenyl)thio]-2-hydroxy-2-methylpropanoic acid(339530-91-5)

Safety Data

• Hazardous Substances Data: 339530-91-5(Hazardous Substances Data)

Usage

General Description

The chemical 3-[(4-Fluorophenyl)thio]-2-hydroxy-2-methylpropanoic acid, also known as fenbufen, is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat pain and inflammation associated with conditions such as arthritis. It works by inhibiting the production of prostaglandins, which are chemicals in the body that cause pain and inflammation. Fenbufen is believed to be effective in reducing pain and inflammation, and it may also have some antioxidant properties. However, like other NSAIDs, fenbufen can cause side effects such as stomach irritation, ulcers, and an increased risk of bleeding. It is important to follow the dosage and usage directions provided by a healthcare professional when using fenbufen.

InChI:InChI=1/C10H11FO3S/c1-10(14,9(12)13)6-15-8-4-2-7(11)3-5-8/h2-5,14H,6H2,1H3,(H,12,13)

Upstream product

• 371-42-6 4-Fluorothiophenol 
• 58653-97-7 methyl 2-methyl-2-oxiranecarboxylate 
• 1098651-01-4 methyl 3-((4-fluorophenyl)thio)-2-hydroxy-2-methylpropanoate 

Downstream Products

• 873014-27-8 2-acetoxy-2-methyl-3-(4-fluorophenylthio) propionic acid 
• 1098651-02-5 C₁₀H₁₀ClFO₂S 
• 1463530-10-0 N-(4-cyano-3-(perfluoroethyl)phenyl)-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methylpropanamide 
• 1365025-71-3 C₁₈H₁₃F₄N₃O₆S 
• 1365025-63-3 C₁₇H₁₃ClF₂N₂O₄S 
• 1365025-55-3 C₁₇H₁₄ClFN₂O₄S 
• 1365025-48-4 C₁₇H₁₅FN₂O₄S 
• 1365025-40-6 C₁₈H₁₃F₄N₃O₄S 
• 1365025-32-6 C₁₇H₁₃ClF₂N₂O₂S 
• 1365025-24-6 C₁₇H₁₄ClFN₂O₂S 
• 1365025-17-7 C₁₇H₁₅FN₂O₂S 
• 90356-78-8 N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide 

Relevant articles and documents

1,2,4-Oxadiazoles: A new class of anti-prostate cancer agents

Sulfide and sulfonyl derivatives of 1,2,4-oxadiazoles were synthesized and screened by MTT assay on the prostate cancer cells, DU-145. Six compounds were identified as potential anti-prostate cancer agents with IC50 values ranging from 0.5 to 5

Procedure for the synthesis of bicalutamide

The object of the invention is an improved procedure for the synthesis of bicalutamide, characterised in that the 2-hydroxy-2-methyl-3-(4-fluorophenylthio) propionic acid initially produced undergoes a step to acylate the hydroxyl group in position 2 to give an intermediate 2-acyloxy-2-methyl-3-(4-fluorophenylthio) propionic acid, which allows the formation of a successive N-[4-cyano-3-(trifluoromethyl)-phenyl-]-3-[4-fluorophenylthio]-2-acyloxy-2-methyl-propionamide intermediate.

Novel process for preparing rac-bicalutamide and its intermediates

The present invention relates to a new process for the synthesis of racemic and optically active bicalutamide starting from ethyl pyruvate and methyl methacrylate. The present invention discloses processes of preparing bicalutamide intermediates including