339549-16-5Relevant academic research and scientific papers
Transition-metal-free synthesis of N-(1-Alkenyl)imidazoles by potassium phosphate-promoted addition reaction of alkynes to imidazoles
Lu, Linhua,Yan, Hong,Liu, Defu,Rong, Guangwei,Mao, Jincheng
supporting information, p. 75 - 78 (2014/01/06)
The addition reaction of alkynes to N-heterocycles by simply heating in DMSO with potassium phosphate is reported. Good yields with high stereoselectivity could be achieved for a range of substrates. The scope is quite general for both amines and phenylac
ORGANISCHE PHOSPHORVERBINDUNGEN 81. HERSTELLUNG VON HETEROCYCLISCH SUBSTITUIERTEN PHOSPHINOXIDEN UND DEREN VERWENDUNG IN DER WITTIG-HORNER REAKTION
Maier, Ludwig,Rist, G.
, p. 65 - 72 (2007/10/02)
The reaction of dimethyl-chloromethylphosphinoxide with the alkali salts of imidazole, pyrazole, triazole, benztriazole, 2-methylimidazole, benzimidazole, tetrazole, and indazole yields the corresponding dimethyl-heterocyclic substituted methylphosphine oxides 1a-1i.These phosphine oxides easily undergo a Wittig-Horner reaction when treated with aldehydes and ketones and give a cis/trans = 1:1 mixture of the corresponding olefines 2a, 2a', 2b, 2d and 2f.Several of these can be separated by flash chromatography into the pure cis and trans isomers.It was observed that only the cis compounds exhibit fungicidal activity against Erysiphe graminis.
