339580-47-1

Upstream product

• 299167-34-3 2-amino-4-(4-bromophenyl)-5,6,7,8-tetrahydro-5-oxo-4H-chromene-3-carbonitrile 
• 504-02-9 1,3-cylohexanedione 
• 105-07-7 4-cyanobenzaldehyde 
• 109-77-3 malononitrile 

Relevant academic research and scientific papers

One-pot cascade synthesis of benzopyrans and dihydropyrano[c]chromenes catalyzed by lipase TLIM

Lipase TLIM was reported to be an efficient, commercially available and reusable catalyst for the Knoevenagel-Michael cascade reactions of aldehydes, malononitrile/ethyl cyanoacetate and 4-hydroxycoumarin/1, 3-cyclohexanedione/dimedone in aqueous DMSO. Th

Introduction of bis-imidazolium dihydrogen phosphate as a new green acidic ionic liquid catalyst in the synthesis of arylidene malononitrile, ethyl (E)-3-(aryl)-2-cyanoacrylate and tetrahydrobenzo[b]pyran derivatives

In this work, [H2-Bisim][H2PO4]2 as a novel bis-imidazole-based acidic ionic liquid has been synthesized and characterized with a variety of techniques including FT-IR, 1H, 13C, 31/su

Improvement in nanocomposite host (nanocavity of dealuminated zeolite Y)-guest (12-molybdophosphoric acid) catalytic activity and its application to the one-pot three-component synthesis of tetrahydrobenzo[b]pyrans

Zeolite Y was dealuminated by chemical methods (with ethylenediaminetetraacetic acid) to modify the zeolite structure for 12-molybdophosphoric acid (MPA) loading. MPA was encapsulated in the nanocavities of modified dealuminated zeolite Y (MDAZY) and char

Benzopyran compound and application thereof

The invention relates to a benzopyran compound and application thereof. The benzopyran compound has a structure formula shown in a formula I. The application is the application of the compound in preparing a biological membrane medicine for resisting the

4-Dialkylaminopyridine modified magnetic nanoparticles: As an efficient nano-organocatalyst for one-pot synthesis of 2-amino-4: H -chromene-3-carbonitrile derivatives in water

A novel heterogeneous magnetic nano-organocatalyst was developed using immobilization of 4-dialkylaminopyridine moieties on Fe3O4 magnetic nanoparticles (MNP-DMAP). It was synthesized using the reaction of MNP-oxiran (MNPO) with N-methylpyridin-4-amine. The MNPO substrate was produced via oxidation of vinyl groups on the surface of vinyl-functionalized MNP (VMNP) using H2O2. To synthesis VMNP, silica-coated magnetic nanoparticles (Fe3O4@SiO2) were reacted with trimethoxy(vinyl)silane. The MNP-DMAP catalyst shows remarkable activity in the synthesis of 2-amino-4H-chromene-3-carbonitrile derivatives using a multicomponent reaction under mild conditions in water as a green solvent. The MNP-DMAP was reusable in this process for at least 10 times without any treatment in its catalytic activity.

Efficient synthesis of 4H-pyran derivatives using a polymeric catalyst based on PVP

A one-pot efficient method for the synthesis of 4H-pyran derivatives has been developed through a multi-component reaction of aldehydes, malononitrile, and 1,3-cyclic diketones using poly(vinylpyrrolidonium) hydrogen sulfate ([PVPH]HSO4) as a h

Nano α-Al2O3 supported ammonium dihydrogen phosphate (NH4H2PO4/Al2O3): Preparation, characterization and its application as a novel and heterogeneous catalyst for the one-pot synthesis of tetrahydrobenzo[b]pyran and pyrano[2,3-c]pyrazole derivatives

A simple, efficient, and environmentally benign route was developed for the preparation of 2-amino-3-cyano-4-aryl-7,7-dimethyl-5,6,7,8-tetrahydrobenzo[b]pyrans and 6-amino-5-cyano-4-aryl-1,4-dihydropyrano[2,3-c]pyrazoles from the condensation of various aldehydes, malononitrile, and 1,3-dicarbonyl compounds (1,3-cyclohexanedione or 5,5-dimethyl-1,3-cyclohexanedione) or 3-methyl-1-phenyl-2-pyrazoline-5-one, using NH4H2PO4/Al2O3 with good yields. The use of easily available catalyst, shorter reaction times, better yields, the simplicity of the reaction, the heterogeneous system, and the easy work up are the advantages of the present method. Characterization of the catalyst was performed by FT-IR spectroscopy, X-ray diffraction (XRD) techniques, thermal analysis (TG/DTG) and Transmission electron microscopy (TEM).

Practical and green protocol for the synthesis of substituted 4H-chromenes using room temperature ionic liquid choline chloride-urea

An efficient and convenient synthesis of substituted 4H-chromenes is described using room temperature ionic liquid (RTIL) choline chloride-urea in one pot under solvent free conditions. Three-component Knoevenagel condensation of an aromatic aldehyde, wit

Per-6-amino-β-cyclodextrin/CuI catalysed cyanation of aryl halides with K4[Fe(CN)6]

Efficient cyanation of aryl halides is achieved using less toxic K 4[Fe(CN)6] as the reagent and amino-β-cyclodextrins as supramolecular ligands for CuI. Four different amino cyclodextrins viz. per-6-amino-β-CD, per-6-methylamino-β-CD, per-6-butyl-amino-β-CD and mono-6-amino-β-CD are prepared and studied. Aryl and heteroaryl nitriles are obtained in good to excellent yield for even bromo derivatives of flavone and 2-aminopyrans. This system uses catalytic amounts (10 mol%) of both copper iodide and per-6-amino-β-cyclodextrin. Easy separation, the absence of nitrogen atmosphere and excellent yield are the other significant outcomes of this protocol. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.