33972-97-3

Usage

Uses

Used in Cardiovascular Medicine:
1-Methylthyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid is used as a therapeutic agent for the treatment of heart conditions, specifically for improving blood flow and oxygen delivery to the heart. This application aids in reducing symptoms associated with angina and heart failure, ultimately enhancing overall heart function.
Used in Sports Doping:
Despite its medical applications, 1-Methylthyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid has gained notoriety for its potential performance-enhancing effects. As a result, it has been banned as a doping substance in professional sports due to its ability to potentially improve athletic performance beyond the natural capabilities of the human body.
Used in Neuroprotective Research:
1-Methylthyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid is also used as a subject of research for its potential neuroprotective properties. Studies are investigating its capacity to protect the nervous system and potentially treat neurological disorders, although this application is still in the exploratory phase.
Used in Cognitive Enhancement Research:
In addition to its cardiovascular and neuroprotective applications, 1-Methylthyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid is being investigated for its potential to enhance cognitive function. Research is exploring whether 1-Methylthyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid can improve memory, focus, and other cognitive abilities, although further studies are required to confirm these effects.

InChI:InChI=1/C7H7NO3/c1-8-3-2-5(7(10)11)4-6(8)9/h2-4H,1H3,(H,10,11)

Upstream product

• 94170-15-7 1-methyl-2-oxo-1,2-dihydropyridin-4-carboxaldehyde 
• 27330-27-4 4-acetyl-1-methylpyridin-2(1H)-one 
• 111961-69-4 4-isopropyloxycarbonyl-1-methylpyridinium iodide 
• 7630-02-6 4-(methoxycarbonyl)-1-methylpyridinium iodide 
• 20845-23-2 methyl 1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylate 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 77-78-1 dimethyl sulfate 
• 10129-59-6 1-methyl-4-ethoxycarbonylpyridinium iodide 
• 872-85-5 pyridine-4-carbaldehyde 
• 55-22-1 pyridine-4-carboxylic acid 
• 125294-42-0 isopropyl pyridine-4-carboxylate 
• 61379-59-7 4-[1,3]dioxolan-2-yl-pyridine 
• 109442-34-4 4-[1,3]dioxolan-2-yl-1-methyl-1H-pyridin-2-one 
• 22282-72-0 2-oxo-1,2-dihydropyridine-4-carboxylic acid 

Downstream Products

• 98996-29-3 1-methyl-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid ethyl ester 
• 6433-99-4 1-Methyl-2-oxo-1,2-dihydro-isonicotinamid 
• 94170-15-7 1-methyl-2-oxo-1,2-dihydropyridin-4-carboxaldehyde 
• 20845-23-2 methyl 1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylate 
• 102000-68-0 1-methyl-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid hydrazide 
• 371765-69-4 4-(hydroxymethyl)-1-methylpyridin-2(1H)-one 
• 220114-82-9 1-Methyl-4-[(E)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-1H-pyridin-2-one 
• 220114-82-9 1-Methyl-4-[(Z)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-1H-pyridin-2-one 
• 84853-99-6 1-Methyl-2-oxo-1,2-dihydro-pyridine-4-carbonyl chloride 

Relevant academic research and scientific papers

Rhodium-Catalyzed C4-Selective C-H Alkenylation of 2-Pyridones by Traceless Directing Group Strategy

A rhodium-catalyzed C4-selective C-H alkenylation of 3-carboxy-2-pyridones with styrenes has been developed. The carboxylic group at the C3 position works as the traceless directing group, and the corresponding C4-alkenylated 2-pyridones are obtained exclusively with concomitant decarboxylation. Unlike the reported procedures, the exclusive C4 selectivity is uniformly observed even in the presence of potentially more reactive C-H bonds at the C5 and C6 positions. By using this strategy, the multiply substituted 2-pyridone can be prepared via sequential C-H functionalization reactions.

NOVEL ARYLALKENE DERIVATIVES AND USE THEREOF AS SELECTIVE ESTROGEN RECEPTOR MODULATORS

The invention provides novel ethylene derivatives represented by Formula I, which may be used as selective estrogen receptor modulators (SERMs) and useful in the prophylaxis and/or treatment of estrogen-dependent conditions or conditions.

SUBSTITUTED PYRAZOLE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS

Disclosed are compounds active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using and making same.

MGluR5 modulators I

The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.

Substituted phenyl farnesyltransferase inhibitors

Compounds of formula (I) or pharmaceutically acceptable salts thereof, inhibit farnesyltransferase. Methods for making the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.

Substituent Effects in Non-Aromatic Nitrogen Heterocycles: Alkaline Hydrolysis of Methyl N-Methyl(oxo)dihydropyridinecarboxylates and Diaza Analogues

Ester hydrolysis studies on some isomeric methoxycarbonyl derivatives of N-methylpyridin-2- and 4-ones show that reaction rates are affected by the relative positions of CO2Me, =O and NMe functions in ways which could not be predicted.However, from limited results for analogous pyrimidine derivatives, it seems that reactivity in these polyfunctional compounds can be predicted from the pyridine data by assuming additivity of effects.