20845-23-2

Upstream product

• 67-56-1 methanol 
• 84853-99-6 1-Methyl-2-oxo-1,2-dihydro-pyridine-4-carbonyl chloride 
• 6313-54-8 2-chloroisonicotinic acid, 
• 22282-72-0 2-oxo-1,2-dihydropyridine-4-carboxylic acid 
• 74-88-4 methyl iodide 
• 33972-97-3 1-methyl-2-oxo-1,2-dihydro-4-pyridinecarboxylic acid 

Downstream Products

• 67-56-1 methanol 
• 33972-97-3 1-methyl-2-oxo-1,2-dihydro-4-pyridinecarboxylic acid 
• 102000-68-0 1-methyl-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid hydrazide 
• 118160-07-9 2,7-dimethylisoquinolin-1(2H)-one 
• 1018680-64-2 4-(5-{(1R)-1-[5-(3-chlorophenyl)isoxazol-3-yl]ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl)-1-methylpyridin-2(1H)-one 
• 132605-57-3 C₂₂H₂₀N₂O₆ 
• 132605-55-1 C₂₄H₂₆N₂O₅ 
• 161030-10-0 methyl 5,6-dimethyl-3-nitro-2-pyridinecarboxylate 
• 139004-83-4 methyl 3-nitro-6-phenyl-2-pyridinecarboxylate 
• 139004-86-7 methyl 6-methyl-3-nitro-4-pyridinecarboxylate 
• 132605-50-6 (1R,2R,6R,7R)-8-Methyl-3,5,9-trioxo-4-phenyl-4,8-diaza-tricyclo[5.2.2.0^2,6]undec-10-ene-10-carboxylic acid methyl ester 

Relevant academic research and scientific papers

NOVEL ARYLALKENE DERIVATIVES AND USE THEREOF AS SELECTIVE ESTROGEN RECEPTOR MODULATORS

The invention provides novel ethylene derivatives represented by Formula I, which may be used as selective estrogen receptor modulators (SERMs) and useful in the prophylaxis and/or treatment of estrogen-dependent conditions or conditions.

MGLUR5 MODULATORS

The present invention is directed to compounds of formula (I) Wherein R1 to R5, X and Z are further defined in the description. The invention also relates to processes for the preparation of the compounds and to intermediates used in

SUBSTITUTED PYRAZOLE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS

Disclosed are compounds active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using and making same.

MGluR5 modulators I

The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.

Substituent Effects in Non-Aromatic Nitrogen Heterocycles: Alkaline Hydrolysis of Methyl N-Methyl(oxo)dihydropyridinecarboxylates and Diaza Analogues

Ester hydrolysis studies on some isomeric methoxycarbonyl derivatives of N-methylpyridin-2- and 4-ones show that reaction rates are affected by the relative positions of CO2Me, =O and NMe functions in ways which could not be predicted.However, from limited results for analogous pyrimidine derivatives, it seems that reactivity in these polyfunctional compounds can be predicted from the pyridine data by assuming additivity of effects.